Felpreva®是一种用于猫的现场配方,含有依莫地肽、吡喹酮和替戈拉纳,可对抗澳大利亚麻痹蜱全周期硬蜱的实验性感染

Florian Roeber , Chrissie Jackson , Michael Chambers , Veronica Smith , Jane Hume , Katrin Blazejak , Norbert Mencke
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引用次数: 3

摘要

澳大利亚麻痹蜱全环硬蜱继续对澳大利亚东海岸的伴侣动物构成严重威胁。蜱虫产生一种强效神经毒素,会导致迅速上升的弛缓性麻痹,如果不加以治疗,可能导致动物死亡。目前,在澳大利亚注册的用于治疗和控制猫麻痹蜱虫的产品数量有限。Felpreva®是一种有效的复方制剂,含有依莫司肽、吡喹酮和替戈拉纳。为了研究Felpreva®(2.04%w/vEmodeside、8.14%w/v吡喹酮和9.79%w/vTigolaner)对猫实验性全周期轮虫感染的治疗和长期持续疗效,进行了两项研究。研究第17天,50只猫被纳入研究。这些猫在研究开始前对麻痹蜱全环毒素进行了免疫。治疗前进行的蜱携带能力(TCC)测试证实了对全环毒素的免疫力。猫在第0天接受了一次治疗。第1组猫用安慰剂制剂治疗,第2组猫用Felpreva®治疗。猫在第-14天(蜱携带能力测试)、0、28、56、70、84和91天(第4、8、10、12和13周)受到感染。对猫24小时、48小时和72小时的蜱虫进行计数​h治疗后和感染,但在蜱虫携带能力测试期间除外,当时蜱虫数量约为72​h仅在感染后。24小时和48小时的评估是在没有去除蜱虫的情况下进行的。在72小时评估时间点对蜱虫进行评估、移除和丢弃。在~24小时、~48小时和~72小时时,活蜱虫总数存在显著差异​在处理组和对照组之间观察到感染后h。差异有统计学意义(P​<;​0.05至​<;​0.001)。观察到98.1–100%的治疗效果~72​h感染后至治疗后13周(94天)。这些结果表明,单次使用Felpreva®可有效治疗和控制13周的麻痹蜱感染。
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Efficacy and safety of Felpreva®, a spot-on formulation for cats containing emodepside, praziquantel and tigolaner against experimental infestation with the Australian paralysis tick Ixodes holocyclus

The Australian paralysis tick Ixodes holocyclus continues to be a serious threat to companion animals along Australia’s east coast. The tick produces a potent neurotoxin which causes a rapidly ascending flaccid paralysis, which if left untreated, can result in the death of the animal. There is currently only a limited number of products registered in Australia for the treatment and control of paralysis ticks in cats. Felpreva® is an effective spot-on combination containing emodepside, praziquantel and tigolaner. To investigate the therapeutic and long-term persistent efficacy of Felpreva® (2.04% w/v emodepside, 8.14% w/v praziquantel and 9.79% w/v tigolaner) against experimental infestation with I. holocyclus in cats, two studies were undertaken. Fifty cats were included in the studies on study Day -17. These cats were immunized against paralysis tick holocyclotoxin prior to the study commencing. Immunity to holocyclotoxin was confirmed with a tick carrying capacity (TCC) test conducted prior to treatment. Cats were treated once on Day 0. Group 1 cats were treated with the placebo formulation and Group 2 cats were treated with Felpreva®. Cats were infested on Days -14 (tick carrying capacity test), 0, 28, 56, 70, 84 and 91 (weeks 4, 8, 10, 12 and 13). Ticks were counted on cats 24 h, 48 h and 72 ​h post-treatment and infestation, except during the tick carrying capacity test when they were counted approximately 72 ​h post-infestation only. The 24-h and 48-h assessments were conducted without removing the ticks. The ticks were assessed, removed and discarded at the 72-h assessment time-points. Significant differences in total live tick counts at ∼24 h, ∼48 h and ∼72 ​h post-infestation were observed between the treatment and control group. Differences were significant (P ​< ​0.05 to ​< ​0.001) in all instances. Treatment efficacies of 98.1–100% were observed ∼72 ​h post-infestation through to 13 weeks (94 days) post-treatment. These results show that a single application of Felpreva® provides effective treatment and control against induced infestation with paralysis ticks for 13 weeks.

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