{"title":"非编码RNA在内皮细胞功能中的新作用","authors":"Tijana Mitić, Andrea Caporali","doi":"10.1016/j.cophys.2023.100672","DOIUrl":null,"url":null,"abstract":"<div><p>Nearly 98% of the human genome is transcriptionally active but does not encode proteins, reflecting a wide range of noncoding genomes with essential regulatory and structural roles. Understanding the endothelial cell (EC) function in vascular biology has been pivotal for grasping the repair mechanisms in ischaemic tissue and during cardiovascular diseases. However, only a tiny portion of the human genome's noncoding region has been studied to understand its role in new mechanisms in EC biology. Herein, we provide an overview of the non-coding RNAs (ncRNAs) in endothelium. We also discuss the latest research focusing on canonical and noncanonical aspects in ncRNA biology, ncRNA, cell-to-cell communication and transcriptional and epigenetic regulation by ncRNA in the endothelium.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"34 ","pages":"Article 100672"},"PeriodicalIF":2.5000,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Emerging roles of non-coding RNAs in endothelial cell function\",\"authors\":\"Tijana Mitić, Andrea Caporali\",\"doi\":\"10.1016/j.cophys.2023.100672\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Nearly 98% of the human genome is transcriptionally active but does not encode proteins, reflecting a wide range of noncoding genomes with essential regulatory and structural roles. Understanding the endothelial cell (EC) function in vascular biology has been pivotal for grasping the repair mechanisms in ischaemic tissue and during cardiovascular diseases. However, only a tiny portion of the human genome's noncoding region has been studied to understand its role in new mechanisms in EC biology. Herein, we provide an overview of the non-coding RNAs (ncRNAs) in endothelium. We also discuss the latest research focusing on canonical and noncanonical aspects in ncRNA biology, ncRNA, cell-to-cell communication and transcriptional and epigenetic regulation by ncRNA in the endothelium.</p></div>\",\"PeriodicalId\":52156,\"journal\":{\"name\":\"Current Opinion in Physiology\",\"volume\":\"34 \",\"pages\":\"Article 100672\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2023-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Opinion in Physiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2468867323000421\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PHYSIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Physiology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468867323000421","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
Emerging roles of non-coding RNAs in endothelial cell function
Nearly 98% of the human genome is transcriptionally active but does not encode proteins, reflecting a wide range of noncoding genomes with essential regulatory and structural roles. Understanding the endothelial cell (EC) function in vascular biology has been pivotal for grasping the repair mechanisms in ischaemic tissue and during cardiovascular diseases. However, only a tiny portion of the human genome's noncoding region has been studied to understand its role in new mechanisms in EC biology. Herein, we provide an overview of the non-coding RNAs (ncRNAs) in endothelium. We also discuss the latest research focusing on canonical and noncanonical aspects in ncRNA biology, ncRNA, cell-to-cell communication and transcriptional and epigenetic regulation by ncRNA in the endothelium.
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