Anja Angelov , Paul J Connelly , Christian Delles , Georgios Kararigas
{"title":"载脂蛋白A1的性别偏向性和性激素依赖性调控","authors":"Anja Angelov , Paul J Connelly , Christian Delles , Georgios Kararigas","doi":"10.1016/j.cophys.2023.100654","DOIUrl":null,"url":null,"abstract":"<div><p><span><span>Pronounced sex differences in the development and outcome of cardiovascular diseases (CVD) exist. Apolipoprotein A1 (APOA1), the basic </span>structural protein of high-density lipoprotein (HDL), is involved in key metabolic processes. However, its role in the pathogenesis of CVD is incompletely understood. The effects of biological sex on factors influencing the APOA1-lipid balance and the underlying mechanisms are also poorly understood. Here, we summarize evidence supporting sex-biased and sex hormone-dependent regulation of APOA1. In particular, we discuss sex-biased </span><em>APOA1</em> genetic variation, sex differences in APOA1 regulation and cardiovascular physiology, and sex hormone-dependent regulation of APOA1 in cis- and transgender individuals. We put forward that studying the effects of biological sex will contribute to a better understanding of the role of APOA1 in cardiovascular physiology and its sex-biased association with CVD. Importantly, in situations of sex hormone therapy or inhibition, more sex-stratified data are required to inform clinical management of APOA1-related cardiovascular risk in a sex-dependent manner.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"33 ","pages":"Article 100654"},"PeriodicalIF":1.9000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Sex-biased and sex hormone-dependent regulation of apolipoprotein A1\",\"authors\":\"Anja Angelov , Paul J Connelly , Christian Delles , Georgios Kararigas\",\"doi\":\"10.1016/j.cophys.2023.100654\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span><span>Pronounced sex differences in the development and outcome of cardiovascular diseases (CVD) exist. Apolipoprotein A1 (APOA1), the basic </span>structural protein of high-density lipoprotein (HDL), is involved in key metabolic processes. However, its role in the pathogenesis of CVD is incompletely understood. The effects of biological sex on factors influencing the APOA1-lipid balance and the underlying mechanisms are also poorly understood. Here, we summarize evidence supporting sex-biased and sex hormone-dependent regulation of APOA1. In particular, we discuss sex-biased </span><em>APOA1</em> genetic variation, sex differences in APOA1 regulation and cardiovascular physiology, and sex hormone-dependent regulation of APOA1 in cis- and transgender individuals. We put forward that studying the effects of biological sex will contribute to a better understanding of the role of APOA1 in cardiovascular physiology and its sex-biased association with CVD. Importantly, in situations of sex hormone therapy or inhibition, more sex-stratified data are required to inform clinical management of APOA1-related cardiovascular risk in a sex-dependent manner.</p></div>\",\"PeriodicalId\":52156,\"journal\":{\"name\":\"Current Opinion in Physiology\",\"volume\":\"33 \",\"pages\":\"Article 100654\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2023-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Opinion in Physiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S246886732300024X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/3/9 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"PHYSIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Physiology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S246886732300024X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/3/9 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
Sex-biased and sex hormone-dependent regulation of apolipoprotein A1
Pronounced sex differences in the development and outcome of cardiovascular diseases (CVD) exist. Apolipoprotein A1 (APOA1), the basic structural protein of high-density lipoprotein (HDL), is involved in key metabolic processes. However, its role in the pathogenesis of CVD is incompletely understood. The effects of biological sex on factors influencing the APOA1-lipid balance and the underlying mechanisms are also poorly understood. Here, we summarize evidence supporting sex-biased and sex hormone-dependent regulation of APOA1. In particular, we discuss sex-biased APOA1 genetic variation, sex differences in APOA1 regulation and cardiovascular physiology, and sex hormone-dependent regulation of APOA1 in cis- and transgender individuals. We put forward that studying the effects of biological sex will contribute to a better understanding of the role of APOA1 in cardiovascular physiology and its sex-biased association with CVD. Importantly, in situations of sex hormone therapy or inhibition, more sex-stratified data are required to inform clinical management of APOA1-related cardiovascular risk in a sex-dependent manner.
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