基于纳米技术的策略推进护理点横向流免疫测定

IF 4.7 3区 工程技术 Q2 ENGINEERING, BIOMEDICAL Current Opinion in Biomedical Engineering Pub Date : 2023-09-09 DOI:10.1016/j.cobme.2023.100504
Peuli Nath, Aniruddha Ray
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引用次数: 0

摘要

护理点测试(POCT)通过在患者护理现场提供快速准确的结果,有可能改变医学诊断。在正在开发的许多不同类型的POCT中,侧流免疫测定法(LFIA)由于其简单、低成本和快速反应时间而被广泛使用。将纳米技术的最新进展与LFIA相结合,极大地提高了它们的灵敏度、特异性、检测极限以及长期稳定性。等离子体激元和荧光纳米粒子都可以用抗体/适体和其他靶向部分进行功能化,从而能够检测广泛的生物标志物。在这里,我们讨论了利用纳米技术提高这些LFIA性能的各种策略,以打破目前使用的传统检测的限制。这些测试的成功部署将促进广泛使用,从而彻底改变当前的诊断和治疗实践,并遏制未来的流行病。广泛使用这些检测也将减少高昂的医疗支出,这是每个国家医疗改革的中心目标。
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Nanotechnology-based strategies for advancing point-of-care lateral flow immunoassays

Point-of-care tests (POCTs) have the potential to transform medical diagnostics by providing rapid and accurate results at the site of patient care. Of the many different types of POCTs being developed, lateral flow immunoassays (LFIAs) are some of the most widely used due to their simplicity, low cost, and fast response time. Combining recent advances in nanotechnology with the LFIAs has drastically improved their performance in terms of their sensitivity, specificity, and limit of detection, as well as their long-term stability. Nanoparticles, both plasmonic and fluorescent, can be functionalized with antibodies/aptamers and other targeting moieties, thereby enabling the detection of a wide range of biomarkers. Here we discuss various strategies, utilizing nanotechnology, to enhance the performance of these LFIAs in order to break the limits of the currently used conventional assays. Successful deployment of these tests will facilitate widespread use, thereby revolutionizing the current diagnostic and treatment practices, as well as curb future pandemics. Extensive utilization of these tests will also reduce the high medical expenditures, which is a central object of health care reform in every country.

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来源期刊
Current Opinion in Biomedical Engineering
Current Opinion in Biomedical Engineering Medicine-Medicine (miscellaneous)
CiteScore
8.60
自引率
2.60%
发文量
59
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