ω-3多不饱和脂肪酸对帕金森病患者促炎和抗炎细胞因子水平及脂质状况的影响

IF 0.5 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM Nutrition Clinique et Metabolisme Pub Date : 2023-09-01 DOI:10.1016/j.nupar.2023.06.001
Sara Mohammadi , Mirmohsen Sharifi Bonab , Mahdyieh Hamed Behzad , Bahram Pourghassem Gargari
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引用次数: 0

摘要

目的帕金森病(PD)与炎症和血脂异常有关。考虑到ω-3多不饱和脂肪酸(ω-3 PUFA)对炎症和脂质代谢的影响,本研究旨在研究补充ω-3 PUFAs对PD的促炎、抗炎细胞因子和脂质代谢谱的影响。材料和方法本研究选择44例PD患者,分为两组。干预组每天服用两粒ω-3 PUFA胶囊,每粒含有120 mg二十碳五烯酸和180 mg二十二碳六烯酸,安慰剂组每天服用2粒大豆油软胶囊,持续8周。在研究开始和结束时评估了体重、身高、脂质状况(TG、HDL-c、LDL-c、总胆固醇[TC])以及促炎和抗炎细胞因子(IL-6、TNF-α和IL-10)。结果ω-3 PUFAs组的体重指数(P=0.02)、体重(P=0.04)、HDL-c(P=0.01)、LDL-c(P=0.03)和IL-6(P=0.02。组间比较显示,在调整基线值和混杂因素后,变化并不显著。此外,TC的变化在组内或组间比较中均不显著。结论根据研究结果,连续8周补充600 mgω-3 PUFA对PD患者的促炎和抗炎细胞因子及脂质水平没有显著影响。需要进一步进行更高剂量的研究,以更好地阐明ω-3 PUFAs在PD患者生化和临床结果中的作用。
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Effects of omega-3 polyunsaturated fatty acids on the levels of pro- and anti-inflammatory cytokines and lipid profile in patients with Parkinson's disease

Objective

Parkinson's disease (PD) is associated with inflammation and lipid profile abnormalities. Considering the effects of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) on inflammation and lipid metabolism, the present study aimed to investigate the effects of ω-3 PUFAs supplementation on the pro- and anti-inflammatory cytokines and lipid profile in PD.

Material and methods

In this study, 44 patients with PD were selected and divided into two groups. The intervention group received two capsules of ω-3 PUFAs daily, each capsule containing 120 mg eicosapentaenoic acid and 180 mg docosahexaenoic acid, and the placebo group received two soft capsules of soybean oil daily for eight weeks. Weight, height, lipid profile (TG, HDL-c, LDL-c, total cholesterol [TC]), and pro- and anti-inflammatory cytokines (IL-6, TNF-α, and IL-10) were assessed at the beginning and at the end of the study.

Results

Body mass index (P = 0.02), weight (P = 0.04), HDL-c (P = 0.01), LDL-c (P = 0.03), and IL-6 (P = 0.02) levels increased, while TG (P = 0.01), TNF-α (P = 0.01), and IL-10 (P = 0.01) decreased significantly in the ω-3 PUFAs group. Between-group comparisons revealed the changes not to be significant after adjustments for baseline values and confounders. Moreover, the changes in TC were not significant in either within- or between-group comparisons.

Conclusion

Based on the results of the study, 600 mg ω-3 PUFAs supplementation for eight weeks has no significant effect on the assessed pro- and anti-inflammatory cytokines and lipid profiles in patients with PD. Further studies with higher doses are needed to better clarify the role of ω-3 PUFAs in the biochemical and clinical outcomes of PD patients.

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来源期刊
Nutrition Clinique et Metabolisme
Nutrition Clinique et Metabolisme 医学-内分泌学与代谢
CiteScore
0.80
自引率
16.70%
发文量
216
审稿时长
78 days
期刊介绍: Nutrition Clinique et Métabolisme is the journal of the French-speaking Society of Enteral and Parenteral Nutrition. Associating clinicians, biologists, pharmacists, and fundamentalists, the articles presented in the journal concern man and animals, and deal with organs and cells. The goal is a better understanding of the effects of artificial nutrition and human metabolism. Original articles, general reviews, update articles, technical notes and communications are published, as well as editorials and case reports.
期刊最新文献
Editorial board Issue contents Applicability of Global Leadership Initiative on Malnutrition (GLIM) criteria in nutrition risk screening for patients over 60 years old with digestive system tumors – A retrospective study Effect of omega-3 fatty acids supplementation on inflammatory markers following exercise-induced muscle damage: Systematic review and meta-analysis of randomized controlled trials Associations between Diet Inflammatory Index Scores and nutritional status in chronic kidney disease patients
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