机械应力下血管内皮的蛋白酶抑制和弹性

IF 2.5 Q2 PHYSIOLOGY Current Opinion in Physiology Pub Date : 2023-08-01 DOI:10.1016/j.cophys.2023.100673

Adam Keen, Feiran Zhang, John S Reader, Ellie Tzima

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引用次数: 1

摘要

内皮稳态是血管健康的核心特征。血管内皮处于由血流引起的持续机械应力下，因此需要高度的弹性来适应压力和抵抗疾病的发展。在这篇综述中，我们讨论了内皮通过调节三个关键领域:蛋白质合成、循环和降解来维持蛋白质稳态以响应血流动力学力的分子机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Proteostasis and resilience in the mechanically-stressed vascular endothelium

Endothelial homeostasis is a central feature of vascular health. The vascular endothelium is under constant mechanical stress resulting from blood flow and, therefore, requires a high degree of resilience to adapt to stresses and resist development of disease. In this review, we discuss the molecular mechanisms by which the endothelium maintains proteostasis in response to haemodynamic forces by regulating three key areas: protein synthesis, recycling and degradation.

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