帕金森病中的菌群-肠-脑轴:回顾我们所知道的以及我们仍然可以采取哪些途径来推进这一研究领域

IF 5.7 2区 生物学 Q1 MYCOLOGY Fungal Biology Reviews Pub Date : 2023-01-01 DOI:10.1016/j.fbr.2023.100327
Dionisio P. Amorim Neto, Anderson S. Sant’Ana
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引用次数: 0

摘要

微生物-肠-脑轴是一种双向通路,在不同的神经退行性疾病中起作用,如散发性帕金森病。然而,大多数研究只评估了帕金森病患者的肠道细菌生态。在这里,目的是探索肠道微生物群在帕金森病中的作用。研究结果表明,霉菌和酵母或它们的次级代谢产物不仅可以保护帕金森病的主要临床症状,而且还可以诱发帕金森病的主要临床症状。然而,肠道菌群与散发性帕金森病的发病和进展之间仍然没有因果关系。在这篇综述中,真菌被强调为帕金森病病因学的一个可能的关键部分。此外,还提出了可能有助于研究菌群-肠-脑轴的不同实验方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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The mycobiota-gut-brain axis in Parkinson's disease: A review on what we know and what paths we can still take to advance this field of study
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来源期刊
CiteScore
10.60
自引率
0.00%
发文量
36
期刊介绍: Fungal Biology Reviews is an international reviews journal, owned by the British Mycological Society. Its objective is to provide a forum for high quality review articles within fungal biology. It covers all fields of fungal biology, whether fundamental or applied, including fungal diversity, ecology, evolution, physiology and ecophysiology, biochemistry, genetics and molecular biology, cell biology, interactions (symbiosis, pathogenesis etc), environmental aspects, biotechnology and taxonomy. It considers aspects of all organisms historically or recently recognized as fungi, including lichen-fungi, microsporidia, oomycetes, slime moulds, stramenopiles, and yeasts.
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