曲霉种生产曲酸:趋势与应用

IF 5.7 2区 生物学 Q1 MYCOLOGY Fungal Biology Reviews Pub Date : 2023-01-01 DOI:10.1016/j.fbr.2023.100313
Maria Tamara de Caldas Felipe , Renan do Nascimento Barbosa , Jadson Diogo Pereira Bezerra , Cristina Maria de Souza-Motta
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引用次数: 5

摘要

曲酸(KA)主要由曲霉菌产生,是真菌二次代谢的产物,在生物技术上有很大的应用潜力。KA的使用稳步增加,主要是在制药行业,KA用于皮肤闪电。KA的市场近年来大幅增长,预计到2026年将达到3900万美元。在这篇综述中,我们总结了有关KA应用的相关信息,描述了用于生产KA的曲霉菌的最佳培养条件,并评估了KA市场的前景。基于我们的发现,我们确定使用葡萄糖和酵母提取物分别作为碳和氮的主要来源的深层发酵可以获得最高的KA产量。此外,根据文献,被报道为KA最佳生产商的主要物种/菌株是黄曲霉(44-L)、米曲霉(AR-47和NRRL 484)和土曲霉(菌株PTCC 5283的C5-10突变体)。鉴于KA的商业重要性和对这种天然产物日益增长的需求,需要进一步的研究来确定曲霉的新菌株是这种酸的潜在高产菌株。类似地,希望确定用于低成本生产KA的新的底物来源,从而促进其生产用于制药、医疗保健和其他潜在的工业应用。此外,鉴于目前对KA生物合成途径的了解有限,还需要进一步的研究来阐明该生物合成途径。
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Production of kojic acid by Aspergillus species: Trends and applications
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来源期刊
CiteScore
10.60
自引率
0.00%
发文量
36
期刊介绍: Fungal Biology Reviews is an international reviews journal, owned by the British Mycological Society. Its objective is to provide a forum for high quality review articles within fungal biology. It covers all fields of fungal biology, whether fundamental or applied, including fungal diversity, ecology, evolution, physiology and ecophysiology, biochemistry, genetics and molecular biology, cell biology, interactions (symbiosis, pathogenesis etc), environmental aspects, biotechnology and taxonomy. It considers aspects of all organisms historically or recently recognized as fungi, including lichen-fungi, microsporidia, oomycetes, slime moulds, stramenopiles, and yeasts.
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