{"title":"具有非溶细胞治愈和Ornstein-Uhlenbeck过程的随机HIV模型动力学分析","authors":"Cheng Han, Yan Wang, Daqing Jiang","doi":"10.1016/j.chaos.2023.113930","DOIUrl":null,"url":null,"abstract":"<div><p>In this paper, we introduce an HIV infection model with virus-to-cell infection, cell-to-cell infection and non-cytolytic cure. Two mean-reverting Ornstein–Uhlenbeck processes are also taken into account in the model. Firstly, it is proved that the stochastic model has a unique positive global solution. The model is found to have at least one stationary distribution by constructing suitable Lyapunov functions if the critical condition <span><math><mrow><msubsup><mrow><mi>R</mi></mrow><mrow><mn>0</mn></mrow><mrow><mi>s</mi></mrow></msubsup><mo>></mo><mn>1</mn></mrow></math></span>. Then, the probability density function near the quasi-positive equilibrium is obtained by solving the corresponding Fokker–Planck equation. The spectral radius method is used to derive the virus extinction under a sufficient condition <span><math><mrow><msubsup><mrow><mi>R</mi></mrow><mrow><mn>0</mn></mrow><mrow><mi>e</mi></mrow></msubsup><mo><</mo><mn>1</mn></mrow></math></span>. Finally, some numerical simulations are carried out.</p></div>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":null,"pages":null},"PeriodicalIF":8.3000,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Dynamics analysis of a stochastic HIV model with non-cytolytic cure and Ornstein–Uhlenbeck process\",\"authors\":\"Cheng Han, Yan Wang, Daqing Jiang\",\"doi\":\"10.1016/j.chaos.2023.113930\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>In this paper, we introduce an HIV infection model with virus-to-cell infection, cell-to-cell infection and non-cytolytic cure. Two mean-reverting Ornstein–Uhlenbeck processes are also taken into account in the model. Firstly, it is proved that the stochastic model has a unique positive global solution. The model is found to have at least one stationary distribution by constructing suitable Lyapunov functions if the critical condition <span><math><mrow><msubsup><mrow><mi>R</mi></mrow><mrow><mn>0</mn></mrow><mrow><mi>s</mi></mrow></msubsup><mo>></mo><mn>1</mn></mrow></math></span>. Then, the probability density function near the quasi-positive equilibrium is obtained by solving the corresponding Fokker–Planck equation. The spectral radius method is used to derive the virus extinction under a sufficient condition <span><math><mrow><msubsup><mrow><mi>R</mi></mrow><mrow><mn>0</mn></mrow><mrow><mi>e</mi></mrow></msubsup><mo><</mo><mn>1</mn></mrow></math></span>. Finally, some numerical simulations are carried out.</p></div>\",\"PeriodicalId\":5,\"journal\":{\"name\":\"ACS Applied Materials & Interfaces\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":8.3000,\"publicationDate\":\"2023-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Materials & Interfaces\",\"FirstCategoryId\":\"100\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0960077923008317\",\"RegionNum\":2,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Materials & Interfaces","FirstCategoryId":"100","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0960077923008317","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
Dynamics analysis of a stochastic HIV model with non-cytolytic cure and Ornstein–Uhlenbeck process
In this paper, we introduce an HIV infection model with virus-to-cell infection, cell-to-cell infection and non-cytolytic cure. Two mean-reverting Ornstein–Uhlenbeck processes are also taken into account in the model. Firstly, it is proved that the stochastic model has a unique positive global solution. The model is found to have at least one stationary distribution by constructing suitable Lyapunov functions if the critical condition . Then, the probability density function near the quasi-positive equilibrium is obtained by solving the corresponding Fokker–Planck equation. The spectral radius method is used to derive the virus extinction under a sufficient condition . Finally, some numerical simulations are carried out.
期刊介绍:
ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.