具有非溶细胞治愈和Ornstein-Uhlenbeck过程的随机HIV模型动力学分析

IF 5.6 1区 数学 Q1 MATHEMATICS, INTERDISCIPLINARY APPLICATIONS Chaos Solitons & Fractals Pub Date : 2023-10-01 Epub Date: 2023-08-21 DOI:10.1016/j.chaos.2023.113930
Cheng Han, Yan Wang, Daqing Jiang
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引用次数: 0

摘要

本文介绍了一种具有病毒对细胞感染、细胞对细胞感染和非溶细胞治疗的HIV感染模型。模型还考虑了两个均值回归的Ornstein-Uhlenbeck过程。首先,证明了该随机模型具有唯一正全局解。通过构造合适的Lyapunov函数,发现当临界条件r0 >1时,模型至少有一个平稳分布。然后,通过求解相应的Fokker-Planck方程,得到准正平衡附近的概率密度函数。利用谱半径法推导了在充分条件r0 <1下的病毒消光量。最后进行了数值模拟。
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Dynamics analysis of a stochastic HIV model with non-cytolytic cure and Ornstein–Uhlenbeck process

In this paper, we introduce an HIV infection model with virus-to-cell infection, cell-to-cell infection and non-cytolytic cure. Two mean-reverting Ornstein–Uhlenbeck processes are also taken into account in the model. Firstly, it is proved that the stochastic model has a unique positive global solution. The model is found to have at least one stationary distribution by constructing suitable Lyapunov functions if the critical condition R0s>1. Then, the probability density function near the quasi-positive equilibrium is obtained by solving the corresponding Fokker–Planck equation. The spectral radius method is used to derive the virus extinction under a sufficient condition R0e<1. Finally, some numerical simulations are carried out.

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来源期刊
Chaos Solitons & Fractals
Chaos Solitons & Fractals 物理-数学跨学科应用
CiteScore
13.20
自引率
10.30%
发文量
1087
审稿时长
9 months
期刊介绍: Chaos, Solitons & Fractals strives to establish itself as a premier journal in the interdisciplinary realm of Nonlinear Science, Non-equilibrium, and Complex Phenomena. It welcomes submissions covering a broad spectrum of topics within this field, including dynamics, non-equilibrium processes in physics, chemistry, and geophysics, complex matter and networks, mathematical models, computational biology, applications to quantum and mesoscopic phenomena, fluctuations and random processes, self-organization, and social phenomena.
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