具有非溶细胞治愈和Ornstein-Uhlenbeck过程的随机HIV模型动力学分析

IF 8.3 2区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY ACS Applied Materials & Interfaces Pub Date : 2023-10-01 DOI:10.1016/j.chaos.2023.113930
Cheng Han, Yan Wang, Daqing Jiang
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引用次数: 0

摘要

本文介绍了一种具有病毒对细胞感染、细胞对细胞感染和非溶细胞治疗的HIV感染模型。模型还考虑了两个均值回归的Ornstein-Uhlenbeck过程。首先,证明了该随机模型具有唯一正全局解。通过构造合适的Lyapunov函数,发现当临界条件r0 >1时,模型至少有一个平稳分布。然后,通过求解相应的Fokker-Planck方程,得到准正平衡附近的概率密度函数。利用谱半径法推导了在充分条件r0 <1下的病毒消光量。最后进行了数值模拟。
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Dynamics analysis of a stochastic HIV model with non-cytolytic cure and Ornstein–Uhlenbeck process

In this paper, we introduce an HIV infection model with virus-to-cell infection, cell-to-cell infection and non-cytolytic cure. Two mean-reverting Ornstein–Uhlenbeck processes are also taken into account in the model. Firstly, it is proved that the stochastic model has a unique positive global solution. The model is found to have at least one stationary distribution by constructing suitable Lyapunov functions if the critical condition R0s>1. Then, the probability density function near the quasi-positive equilibrium is obtained by solving the corresponding Fokker–Planck equation. The spectral radius method is used to derive the virus extinction under a sufficient condition R0e<1. Finally, some numerical simulations are carried out.

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来源期刊
ACS Applied Materials & Interfaces
ACS Applied Materials & Interfaces 工程技术-材料科学:综合
CiteScore
16.00
自引率
6.30%
发文量
4978
审稿时长
1.8 months
期刊介绍: ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.
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