SPT5在转录中的新作用

IF 2.5 Q3 CELL BIOLOGY Cellular Physiology and Biochemistry Pub Date : 2023-10-23 DOI:10.33594/000000665

Vivek Pandey, Shirani Punniyamoorthy, Yuba Raj Pokharel

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引用次数: 0

摘要

在酵母突变体中发现的Ty同源物抑制剂-5（SPT5）筛选为酵母转座子（Ty）元件与SPT4一起插入引起的突变的抑制剂，与之形成称为DRB敏感性诱导因子（DSIF）的全酶复合物，并在转录调控中发挥重要作用。SPT5是一种高度保守的蛋白质，横跨生命的所有三个结构域，在转录中发挥关键功能，从启动子近端暂停到终止。我们还强调了SPT5在其他非经典功能中的新作用，如翻译后修饰（PTM）的调节和非编码基因的转录调节。此外，简而言之，我们强调了SPT5失调的临床意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Emerging Roles of SPT5 in Transcription.

Suppressor of Ty homolog-5 (SPT5) discovered in the yeast mutant screens as a suppressor of mutation caused by the insertion of the Transposons of yeast (Ty) element along with SPT4, with which it forms a holoenzyme complex known as DRB sensitivity-inducing factor (DSIF) and plays an essential role in the regulation of transcription. SPT5 is a highly conserved protein across all three domains of life and performs critical functions in transcription, starting from promoter-proximal pausing to termination. We also highlight the emerging role of SPT5 in other non-canonical functions, such as the regulation of post-translational modifications (PTM) and the transcriptional regulation of non-coding genes. Also, in brief, we highlight the clinical implications of SPT5 dysregulation.

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来源期刊

Cellular Physiology and Biochemistry 生物-生理学

CiteScore

5.80

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Cellular Physiology and Biochemistry is a multidisciplinary scientific forum dedicated to advancing the frontiers of basic cellular research. It addresses scientists from both the physiological and biochemical disciplines as well as related fields such as genetics, molecular biology, pathophysiology, pathobiochemistry and cellular toxicology & pharmacology. Original papers and reviews on the mechanisms of intracellular transmission, cellular metabolism, cell growth, differentiation and death, ion channels and carriers, and the maintenance, regulation and disturbances of cell volume are presented. Appearing monthly under peer review, Cellular Physiology and Biochemistry takes an active role in the concerted international effort to unravel the mechanisms of cellular function.