{"title":"两种未描述的从牡丹中提取的甾体化合物w . Theob。","authors":"Wen-Jian Gu , Jin-Qin Ying , Mei-Hua Huang , Miao-Yin Fan , Ya-Mei Zhang","doi":"10.1080/14786419.2023.2272286","DOIUrl":null,"url":null,"abstract":"<div><div>Two undescribed steroids, named (15 <em>R</em>)-2,15-dihydroxypregna-1,4-dien-3,16-dione (<strong>1</strong>) and 2,15-dihydroxypregna-1,4,14-trien-3,16-dione (<strong>2</strong>), were isolated from the aerial parts of <em>Munronia pinn</em>ata (Wall.) W. Theob. The structure elucidation of two compounds was performed by using spectroscopic methods and comparing the literature. Compound <strong>2</strong> exhibited inhibitory effect against PTP-1B with an IC<sub>50</sub> value of 152.07 ± 3.33 <em>μ</em>M, and compound <strong>1</strong> was inactive.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 3","pages":"Pages 483-488"},"PeriodicalIF":1.9000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Two undescribed steroids from Munronia pinnata (Wall.) W. Theob\",\"authors\":\"Wen-Jian Gu , Jin-Qin Ying , Mei-Hua Huang , Miao-Yin Fan , Ya-Mei Zhang\",\"doi\":\"10.1080/14786419.2023.2272286\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Two undescribed steroids, named (15 <em>R</em>)-2,15-dihydroxypregna-1,4-dien-3,16-dione (<strong>1</strong>) and 2,15-dihydroxypregna-1,4,14-trien-3,16-dione (<strong>2</strong>), were isolated from the aerial parts of <em>Munronia pinn</em>ata (Wall.) W. Theob. The structure elucidation of two compounds was performed by using spectroscopic methods and comparing the literature. Compound <strong>2</strong> exhibited inhibitory effect against PTP-1B with an IC<sub>50</sub> value of 152.07 ± 3.33 <em>μ</em>M, and compound <strong>1</strong> was inactive.</div></div>\",\"PeriodicalId\":18990,\"journal\":{\"name\":\"Natural Product Research\",\"volume\":\"39 3\",\"pages\":\"Pages 483-488\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Natural Product Research\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S147864192302226X\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S147864192302226X","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
Two undescribed steroids from Munronia pinnata (Wall.) W. Theob
Two undescribed steroids, named (15 R)-2,15-dihydroxypregna-1,4-dien-3,16-dione (1) and 2,15-dihydroxypregna-1,4,14-trien-3,16-dione (2), were isolated from the aerial parts of Munronia pinnata (Wall.) W. Theob. The structure elucidation of two compounds was performed by using spectroscopic methods and comparing the literature. Compound 2 exhibited inhibitory effect against PTP-1B with an IC50 value of 152.07 ± 3.33 μM, and compound 1 was inactive.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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