脂肪肝:进入代谢时代。

IF 3.7 2区 医学 Q2 INFECTIOUS DISEASES Current HIV/AIDS Reports Pub Date : 2023-12-01 Epub Date: 2023-10-26 DOI:10.1007/s11904-023-00669-7
Kara Wegermann, Cynthia Moylan, Susanna Naggie
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引用次数: 0

摘要

综述目的:本综述的目的是总结最近将HIV与代谢功能障碍相关脂肪性肝病(MASLD)联系起来的文献。这是一个紧迫的问题,因为MASLD流行病的规模和迫切需要对PWH中的MASLD采取预防和治疗策略。最近的研究结果:PWH中MASLD的患病率高于以前的估计,接近50%,这取决于MASLD的人群和定义。PWH的MASLD可能是多因素的,因为一般人群中存在的风险因素,如代谢综合征,以及HIV特有的特征,包括全身炎症和ART。他汀类药物治疗可显著减少PWH的主要心血管不良事件。PWH是MASLD的高危人群。筛查具有代谢综合征特征的PWH可以使早期干预措施降低PWH MASLD的发病率和死亡率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Fatty Liver Disease: Enter the Metabolic Era.

Purpose of review: The goal of this review is to summarize the recent literature linking HIV to metabolic dysfunction-associated steatotic liver disease (MASLD). This is a pressing issue due to the scale of the MASLD epidemic and the urgent need for preventive and therapeutic strategies for MASLD in PWH.

Recent findings: The prevalence of MASLD in PWH is higher than previously appreciated, approaching 50% depending on the population and definition of MASLD. MASLD in PWH is likely multifactorial due to risk factors present in the general population such as metabolic syndrome, and features unique to HIV including systemic inflammation and ART. Statin therapy results in a significant reduction in major adverse cardiovascular events in PWH. PWH are at high risk for MASLD. Screening PWH with metabolic syndrome features could enable earlier interventions to reduce morbidity and mortality associated with MASLD in PWH.

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来源期刊
Current HIV/AIDS Reports
Current HIV/AIDS Reports INFECTIOUS DISEASES-
CiteScore
8.10
自引率
2.20%
发文量
45
期刊介绍: This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of HIV/AIDS. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as antiretroviral therapies, behavioral aspects of management, and metabolic complications and comorbidity. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
期刊最新文献
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