2-吡咯酮及其衍生物的出现:从合成到生物学的观点:综述与现状

IF 8.6 2区 化学 Q1 Chemistry Topics in Current Chemistry Pub Date : 2021-09-23 DOI:10.1007/s41061-021-00350-w
Tanveer Ahmad, Tahir Rasheed, Majid Hussain, Komal Rizwan
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引用次数: 5

摘要

吡酮部分存在于天然产物中,可以通过多种合成方法合成,通过化学修饰形成各种衍生物。许多基于吡咯酮的衍生物都是商业上可用的,并且具有生物相容性。它们是有机合成中各种中间体的组成部分。它们具有显著的生物学特性,包括抗菌、抗病毒、细胞毒和抗肿瘤活性。这些特性使它们对药物的开发很有价值。综述了近年来2-吡咯酮及其衍生物的合成研究进展及其潜在的应用前景。在合成方法方面,重点是无金属和过渡金属催化反应。
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Emergence of 2-Pyrone and Its Derivatives, from Synthesis to Biological Perspective: An Overview and Current Status

Pyrone moieties are present in natural products and can be synthesized by a diverse range of synthetic methods, resulting in the formation of various derivatives through chemical modifications. Many pyrone-based derivatives are commercially available and are biocompatible. They are building blocks of various intermediates in organic synthesis. They possess remarkable biological properties including antimicrobial, antiviral, cytotoxic, and antitumor activity. These characteristics have made them valuable for the development of drugs. We have summarized recent developments in the synthesis of 2-pyrone and its derivatives and their potential applications. With regard to synthetic approaches, the focus has been on metal-free and transition metal-catalyzed reactions.

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来源期刊
Topics in Current Chemistry
Topics in Current Chemistry 化学-化学综合
CiteScore
11.70
自引率
1.20%
发文量
0
审稿时长
6-12 weeks
期刊介绍: Topics in Current Chemistry provides in-depth analyses and forward-thinking perspectives on the latest advancements in chemical research. This renowned journal encompasses various domains within chemical science and their intersections with biology, medicine, physics, and materials science. Each collection within the journal aims to offer a comprehensive understanding, accessible to both academic and industrial readers, of emerging research in an area that captivates a broader scientific community. In essence, Topics in Current Chemistry illuminates cutting-edge chemical research, fosters interdisciplinary collaboration, and facilitates knowledge-sharing among diverse scientific audiences.
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