中药保留灌肠治疗放射性直肠炎疗效的系统评价

Xin-Man Wang , Song-Ge An , Lin Yang , Fan-Jie Meng
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引用次数: 2

摘要

目的系统评价中药保留灌肠治疗放射性直肠炎的疗效。方法检索Cochrane Library、PubMed、EMBASE、EBSCO、ISI、CNKI、VIP、万方数据和CBM数据库中有关中药保留灌肠治疗放射性直肠炎的随机对照试验报告。发表时间为创刊期至2014年5月,由两位审稿人按照纳入和排除标准独立进行文献筛选、数据提取、质量评价和交叉检查。采用RevMan 5.3软件进行meta分析。结果共纳入14项rct,其中仅有10项rct纳入meta分析,共702例患者。meta分析显示,放射性直肠炎患者中药保留灌肠总疗效高于对照组,RR = 4.83, 95% CI (2.98, 7.84), P <0.000 01;四项研究结果表明,中药保留灌肠对临床症状的改善程度高于对照组。结论中药保留灌肠可提高放射性直肠炎患者的总疗效,缓解放射性直肠炎的症状。
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Systematic evaluation on curative effects of traditional Chinese medicine retention enemas for patients with radiation proctitis

Objectives

To systematically evaluate the curative effects of traditional Chinese medicine retention enemas for patients with radiation proctitis.

Methods

Reports on randomized controlled trials (RCTs) on traditional Chinese medicine retention enemas in the treatment of radiation proctitis were searched in the Cochrane Library, PubMed, EMBASE, EBSCO, ISI, CNKI, VIP, WanFang Data and CBM databases. The publication dates were from inception to May 2014, and a literature screening, data extraction, quality evaluation and cross checks were independently conducted by two reviewers in accordance with the inclusion and exclusion criteria. A meta-analysis was then carried out using RevMan 5.3 software.

Results

In total, 14 RCTs were included, and of these, only 10 RCTs involving 702 patients were included in the meta-analysis. The meta-analysis showed that the total efficacy of traditional Chinese medicine retention enemas was higher for patients with radiation proctitis compared with that in control group, RR = 4.83, 95% CI (2.98, 7.84), P < 0.000 01; the results from four studies indicated that the improvement of clinical symptoms due to traditional Chinese medicine retention enemas was higher than that of the control group.

Conclusions

The implementation of traditional Chinese medicine retention enemas could improve the total efficacy of treatment and provide relief in patients with radiation proctitis.

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