外伤后癫痫免疫炎症机制研究进展。

IF 3.6 4区 医学 Q3 CELL BIOLOGY Cellular and Molecular Neurobiology Pub Date : 2023-11-01 Epub Date: 2023-10-27 DOI:10.1007/s10571-023-01429-2
Yangbin Dang, Tiancheng Wang
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引用次数: 0

摘要

创伤后癫痫(PTE)是由大脑上的各种暴力行为引起的创伤性脑损伤引起的严重并发症。PTE发病机制的潜在机制是复杂的,尚未完全确定。大约三分之一的PTE患者对抗癫痫治疗具有耐药性。最近的研究证据表明,神经炎症在PTE的发展中至关重要。本文综述了有关小胶质细胞活化、星形胶质细胞增殖、炎症信号通路、慢性神经炎症和肠道菌群的免疫炎症机制。这些机制为PTE的病理生理机制提供了新的见解,并对PTE的预防和治疗具有开创性意义。创伤后癫痫中神经胶质细胞和肠道微生物群之间的免疫炎症串扰。该图形摘要描述了小胶质细胞和星形胶质细胞在创伤后癫痫中的作用,强调了肠道微生物群对其功能的影响。TBI创伤性脑损伤,AQP4水通道蛋白-4,Kir4.1内向整流K通道。
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Research Progress on the Immune-Inflammatory Mechanisms of Posttraumatic Epilepsy.

Posttraumatic epilepsy (PTE) is a severe complication arising from a traumatic brain injury caused by various violent actions on the brain. The underlying mechanisms for the pathogenesis of PTE are complex and have not been fully defined. Approximately, one-third of patients with PTE are resistant to antiepileptic therapy. Recent research evidence has shown that neuroinflammation is critical in the development of PTE. This article reviews the immune-inflammatory mechanisms regarding microglial activation, astrocyte proliferation, inflammatory signaling pathways, chronic neuroinflammation, and intestinal flora. These mechanisms offer novel insights into the pathophysiological mechanisms of PTE and have groundbreaking implications in the prevention and treatment of PTE. Immunoinflammatory cross-talk between glial cells and gut microbiota in posttraumatic epilepsy. This graphical abstract depicts the roles of microglia and astrocytes in posttraumatic epilepsy, highlighting the influence of the gut microbiota on their function. TBI traumatic brain injury, AQP4 aquaporin-4, Kir4.1 inward rectifying K channels.

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来源期刊
CiteScore
7.70
自引率
0.00%
发文量
137
审稿时长
4-8 weeks
期刊介绍: Cellular and Molecular Neurobiology publishes original research concerned with the analysis of neuronal and brain function at the cellular and subcellular levels. The journal offers timely, peer-reviewed articles that describe anatomic, genetic, physiologic, pharmacologic, and biochemical approaches to the study of neuronal function and the analysis of elementary mechanisms. Studies are presented on isolated mammalian tissues and intact animals, with investigations aimed at the molecular mechanisms or neuronal responses at the level of single cells. Cellular and Molecular Neurobiology also presents studies of the effects of neurons on other organ systems, such as analysis of the electrical or biochemical response to neurotransmitters or neurohormones on smooth muscle or gland cells.
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