核片层蛋白的新功能:为核滴提供表面张力。

IF 4.7 3区 工程技术 Q2 ENGINEERING, BIOMEDICAL Current Opinion in Biomedical Engineering Pub Date : 2023-12-01 Epub Date: 2023-06-20 DOI:10.1016/j.cobme.2023.100483
Richard B Dickinson, Tanmay P Lele
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引用次数: 0

摘要

核薄层是后生动物中的一种保守结构,为核包膜提供机械刚性。核薄层水平的下降和/或核薄层突变与一系列人类疾病有关。尽管核薄层只有大约 15 纳米厚,但对核薄层成分的扰动会通过尚不十分清楚的机制极大地影响整个细胞核的变形反应。在这里,我们讨论了最近提出的 "核下降 "模型的证据,该模型解释了A型片层蛋白在迁移细胞核变形中的作用。在这一模型中,核薄层作为一个不可伸展的表面,在完全展开时支持表面张力,平衡核内部压力。就像液滴表面的分子薄界面在外力作用下控制着表面张力和液滴形状一样,薄核薄层对核滴施加表面张力,以抵抗核变形并确定核形状。我们讨论了核液滴模型对这一至关重要的真核生物细胞器功能的影响。
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A new function for nuclear lamins: providing surface tension to the nuclear drop.

The nuclear lamina, a conserved structure in metazoans, provides mechanical rigidity to the nuclear envelope. A decrease in lamin levels and/or lamin mutations are associated with a host of human diseases. Despite being only about 15 nm thick, perturbation of components of the nuclear lamina dramatically impacts the deformation response of the entire nucleus through mechanisms that are not well understood. Here we discuss evidence for the recently proposed 'nuclear drop' model that explains the role of A-type lamins in nuclear deformation in migrating cells. In this model, the nuclear lamina acts as an inextensible surface, supporting a surface tension when fully unfolded, that balances nuclear interior pressure. Much like a liquid drop surface where the molecularly thin interface governs surface tension and drop shape under external forces, the thin nuclear lamina imparts a surface tension on the nuclear drop to resist nuclear deformation as well as to establish nuclear shape. We discuss implications of the nuclear drop model for the function of this crucially important eukaryotic organelle.

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来源期刊
Current Opinion in Biomedical Engineering
Current Opinion in Biomedical Engineering Medicine-Medicine (miscellaneous)
CiteScore
8.60
自引率
2.60%
发文量
59
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