小檗乙醇提取物的药理作用。叶片对雄性大鼠性行为和精子发生的影响

IF 0.6 4区医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Journal of Mens Health Pub Date : 2012-12-01 DOI:10.1016/j.jomh.2011.12.003

Devendra K. Soni MPharm, Vikas Sharma MPharm, Nagendra Singh Chauhan PhD, V.K. Dixit PhD

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引用次数: 12

摘要

背景紫檀。(P. foetida)被认为是一种壮阳药，但其刺激性行为的能力尚未报道。本研究探讨了足底草乙醇提取物对雄性大鼠性行为和睾酮水平的影响。方法以白化病雄性大鼠为研究对象，研究了50、100和200 mg/kg体重的白化病叶片乙醇提取物对雄性大鼠体重、第二性器官重、性行为、精子发生和血清睾酮水平的影响。结果白化病大鼠灌胃提取物对各组动物均有明显的合成代谢和生精作用。提取物显著提高了安装频率和透射频率。此外，它还显著降低了挂载和导入延迟。这些影响与定向活动的增加有关。结论黄芪提取物对血清睾酮水平有剂量依赖性影响。研究结果支持了牛膝草作为春药在传统医学中的应用。

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Effect of ethanolic extract of Paederia foetida Linn. leaves on sexual behavior and spermatogenesis in male rats

Background

Paederia foetida Linn. (P. foetida) is considered to be an aphrodisiac, but its ability to stimulate sexual behavior has not been reported. In the present study, the effects of an ethanolic extract of P. foetida on sexual behavior and testosterone level in male rats was investigated.

Methods

Ethanolic extract of the leaves (50, 100 and 200 mg/kg body weight) was studied for their effect on body and secondary sexual organ weight, sexual behavior, spermatogenesis and serum testosterone level in male albino rats.

Results

Oral administration of the extract in albino rats showed pronounced anabolic and spermatogenic effects in animals in the treated groups. The extract significantly increased both mount and intromission frequency. In addition, it also significantly reduced both mount and intromission latency. These effects were associated with an increase in orientation activity.

Conclusion

The extract had a dose-dependent influence on serum testosterone level. The results support the use of P. foetida as an aphrodisiac in traditional medicine.

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来源期刊

Journal of Mens Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

0.90

自引率

28.60%

发文量

153

审稿时长

>12 weeks

期刊介绍： JOMH is an international, peer-reviewed, open access journal. JOMH publishes cutting-edge advances in a wide range of diseases and conditions, including diagnostic procedures, therapeutic management strategies, and innovative clinical research in gender-based biology. It also addresses sexual disparities in health, life expectancy, lifestyle and behaviors and so on. Scientists are encouraged to publish their experimental, theoretical, and descriptive studies and observations in as much detail as possible.