Concentraciones plasmáticas de isoprostano-8 en preeclampsia y eclampsia

Objective

To compare plasma vascular 8-isoprostane concentrations in pregnant women with pre-eclampsia and eclampsia.

Material and methods

Patients attending the Hospital Central Dr. Urquinaona in Maracaibo, Venezuela, were selected. The study included 30 patients with mild pre-eclampsia (group A), 30 patients with severe pre-eclampsia (group B), and 30 patients with eclampsia (group C). A control group was also included, consisting of 30 healthy pregnant women (group D) of similar age and body mass index to studied groups. Only nulliparous patients were included. Plasma samples were collected for the 8-isoprostane determination from all patients before delivery, and in the studied groups immediately after diagnosis.

Results

Statistically significant differences were found in gestational age between groups B and C compared with the control group (p < .05). Higher values of plasma 8-isoprostane were observed in severe pre-eclampsia patients (366.0 ± 29.7 pg/mL), as well as in eclampsia patients (354.2 ± 26.9 pg/mL). Lower values were found in mild pre-eclampsia patients (302.2 ± 31.6 pg/mL). The studied groups had significantly higher values of plasma 8-isoprostane compared with controls (209.3 ± 19.1 pg/mL; p < .05). Linear regression analysis found that the factor that was significantly associated with 8-isoprostane concentrations was the 24-h urine protein level (p < .05).

Conclusion

Eclampsia and pre-eclampsia patients had higher plasma 8-isoprostane concentrations than healthy normotensive pregnant women.