最小烯胺类在环叔胺的毒性和解毒中的作用。

NIDA research monograph Pub Date : 1997-01-01 DOI:10.1037/e495572006-009

L. Sayre, D. Engelhart, D. Nadkarni, M. K. Manoj Babu, A. M. Flammang, G. Mccoy

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引用次数: 13

摘要

脂肪族环叔胺是一类天然存在的和合成的靶向中枢生物胺受体的药物。已知这些胺的微粒体代谢与相关代谢P-450同工酶的低共价结合和/或自杀性失活有关;两个比较臭名昭著的例子是苯环利定(1-(1苯基环己基)哌啶)(PCP) (Hoag等人，1984年)和尼古丁(Shigenaga等人，1988年)。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The role of iminium-enamine species in the toxication and detoxication of cyclic tertiary amines.

Aliphatic cyclic tertiary amines constitute a major class of naturally occurring and synthetic drugs directed at central biogenic amine receptors. Microsomal metabolism of these amines is known to be associated with low levels of covalent binding and/or suicide inactivation of the pertinent metabolizing P-450 isozymes; two of the more notorious examples are phencyclidine (1-(1phenylcyclohexyl)piperidine) (PCP) (Hoag et al. 1984) and nicotine (Shigenaga et al. 1988).

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NIDA research monograph

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