Pub Date : 2020-02-01Epub Date: 2019-11-21DOI: 10.1037/adb0000525
Jemma E Cook, Cassie Chandler, Daniela Rüedi-Bettschen, Ian Taylor, Sean Patterson, Donna M Platt
Resurgence may be a mechanism of relapse in alcohol use disorder patients upon discharge from treatment as part of an abuse-treatment-relapse cycle. Adjunctive pharmacotherapies may be a means to facilitate behavioral treatments and block resurgence. Experiments were conducted using a model of alcohol self-administration to assess the repeatability of the elimination and resurgence of alcohol-maintained behavior and the effects of naltrexone. Experiments had three phases. In Phase 1, behavior was maintained by oral alcohol under a fixed-ratio schedule. In Phase 2, behavior was extinguished via condensed milk delivery under a differential-reinforcement-of-other-behavior (DRO) schedule. In Phase 3, the DRO schedule was eliminated. In Experiment 1, this 3-phase cycle was replicated 4 times. Across replications, response rates and dose of alcohol consumed did not differ in Phase 1, alcohol-maintained behavior was eliminated more rapidly in Phase 2, and the resurgence effect was generally stable in Phase 3. In Experiment 2, naltrexone was administered in Phase 2, Phase 3, or both Phases 2 and 3, to separate groups of rats. Naltrexone facilitated the elimination of alcohol-maintained behavior in Phase 2 and, the resurgence of alcohol-maintained behavior was reduced only for those rats that received naltrexone in both phases. Together, these experiments demonstrate that the resurgence of alcohol-maintained behavior is replicable within-subjects and, further, resurgence of alcohol-maintained behavior may be a useful model to evaluate pharmacological interventions to facilitate behavioral treatments and reduce the likelihood of relapse. Results with naltrexone support the use of medication-assisted therapy approaches to reduce relapse risk in patients. (PsycINFO Database Record (c) 2020 APA, all rights reserved).
{"title":"Changes in the elimination and resurgence of alcohol-maintained behavior in rats and the effects of naltrexone.","authors":"Jemma E Cook, Cassie Chandler, Daniela Rüedi-Bettschen, Ian Taylor, Sean Patterson, Donna M Platt","doi":"10.1037/adb0000525","DOIUrl":"10.1037/adb0000525","url":null,"abstract":"<p><p>Resurgence may be a mechanism of relapse in alcohol use disorder patients upon discharge from treatment as part of an abuse-treatment-relapse cycle. Adjunctive pharmacotherapies may be a means to facilitate behavioral treatments and block resurgence. Experiments were conducted using a model of alcohol self-administration to assess the repeatability of the elimination and resurgence of alcohol-maintained behavior and the effects of naltrexone. Experiments had three phases. In Phase 1, behavior was maintained by oral alcohol under a fixed-ratio schedule. In Phase 2, behavior was extinguished via condensed milk delivery under a differential-reinforcement-of-other-behavior (DRO) schedule. In Phase 3, the DRO schedule was eliminated. In Experiment 1, this 3-phase cycle was replicated 4 times. Across replications, response rates and dose of alcohol consumed did not differ in Phase 1, alcohol-maintained behavior was eliminated more rapidly in Phase 2, and the resurgence effect was generally stable in Phase 3. In Experiment 2, naltrexone was administered in Phase 2, Phase 3, or both Phases 2 and 3, to separate groups of rats. Naltrexone facilitated the elimination of alcohol-maintained behavior in Phase 2 and, the resurgence of alcohol-maintained behavior was reduced only for those rats that received naltrexone in both phases. Together, these experiments demonstrate that the resurgence of alcohol-maintained behavior is replicable within-subjects and, further, resurgence of alcohol-maintained behavior may be a useful model to evaluate pharmacological interventions to facilitate behavioral treatments and reduce the likelihood of relapse. Results with naltrexone support the use of medication-assisted therapy approaches to reduce relapse risk in patients. (PsycINFO Database Record (c) 2020 APA, all rights reserved).</p>","PeriodicalId":76229,"journal":{"name":"NIDA research monograph","volume":"98 1","pages":"10-22"},"PeriodicalIF":3.4,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79798955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-29DOI: 10.1136/rapm-2019-100852
Enrique Monzó, Admir Hadzic
{"title":"Costoclavicular approach to the brachial plexus block: simple or double injection?","authors":"Enrique Monzó, Admir Hadzic","doi":"10.1136/rapm-2019-100852","DOIUrl":"10.1136/rapm-2019-100852","url":null,"abstract":"","PeriodicalId":76229,"journal":{"name":"NIDA research monograph","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79795858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-31DOI: 10.22740/KDI.RM.E.2016.01
Soonhee Kim
Kim, Soonhee.2016.Participatory governance and policy diffusion in local governments in Korea,Report,Sejong, South KoreaKorea Development Institute,Research monograph/2016-01,133
{"title":"Participatory governance and policy diffusion in local governments in Korea Implementation of participatory budgeting","authors":"Soonhee Kim","doi":"10.22740/KDI.RM.E.2016.01","DOIUrl":"https://doi.org/10.22740/KDI.RM.E.2016.01","url":null,"abstract":"Kim, Soonhee.2016.Participatory governance and policy diffusion in local governments in Korea,Report,Sejong, South KoreaKorea Development Institute,Research monograph/2016-01,133","PeriodicalId":76229,"journal":{"name":"NIDA research monograph","volume":"107 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72393843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-12-31DOI: 10.22740/KDI.RM.E.2014.02
Shun Wang
Subjective well-being has attracted sharply increasing attention among researchers and policy makers in recent years. The public also pays a lot of attention to it, evidenced by the heavy use of the word “happiness†in media. Some researchers argue that subjective well-being measures should serve as important and reliable measures of human well-being, complementary to the more traditional, more material wellbeing measures such as Gross National Income (GNI). The World Happiness Report 2012 and 2013 strongly support the idea. One of the main agenda of the government of Korea is to increase the happiness of each citizen. However, there is no comprehensive study on Korea’s subjective well-being to guide policy makers. This study is the first comprehensive investigation into subjective well-being in Korea, aiming to show a clearer and more complete picture of Korea’s subjective well-being, including its past and current status, its distribution over time, cohorts, and regions, and its determinants, based on the vast majority of available data.
{"title":"Measuring and Explaining Subjective Well-being in Korea","authors":"Shun Wang","doi":"10.22740/KDI.RM.E.2014.02","DOIUrl":"https://doi.org/10.22740/KDI.RM.E.2014.02","url":null,"abstract":"Subjective well-being has attracted sharply increasing attention among researchers and policy makers in recent years. The public also pays a lot of attention to it, evidenced by the heavy use of the word “happiness†in media. Some researchers argue that subjective well-being measures should serve as important and reliable measures of human well-being, complementary to the more traditional, more material wellbeing measures such as Gross National Income (GNI). The World Happiness Report 2012 and 2013 strongly support the idea. One of the main agenda of the government of Korea is to increase the happiness of each citizen. However, there is no comprehensive study on Korea’s subjective well-being to guide policy makers. This study is the first comprehensive investigation into subjective well-being in Korea, aiming to show a clearer and more complete picture of Korea’s subjective well-being, including its past and current status, its distribution over time, cohorts, and regions, and its determinants, based on the vast majority of available data.","PeriodicalId":76229,"journal":{"name":"NIDA research monograph","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81009807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"EVALUATION OF DRUG ABUSE TREATMENT MEDICATIONS: CONCORDANCE BETWEEN CLINICAL AND PRECLINICAL STUDIES.","authors":"N K Mello","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76229,"journal":{"name":"NIDA research monograph","volume":"185 ","pages":"82-104"},"PeriodicalIF":0.0,"publicationDate":"2005-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1538975/pdf/nihms9909.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26197796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Toward an account of individual differences in drug abuse.","authors":"J H Woods","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76229,"journal":{"name":"NIDA research monograph","volume":"169 ","pages":"2-5"},"PeriodicalIF":0.0,"publicationDate":"1998-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20602673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Stress, the hypothalamic-pituitary-adrenal axis, and vulnerability to drug abuse.","authors":"N E Goeders","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76229,"journal":{"name":"NIDA research monograph","volume":"169 ","pages":"83-104"},"PeriodicalIF":0.0,"publicationDate":"1998-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20602677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Addictive behavior with and without pharmacologic action: critical role of stimulus control.","authors":"J L Falk","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76229,"journal":{"name":"NIDA research monograph","volume":"169 ","pages":"134-53"},"PeriodicalIF":0.0,"publicationDate":"1998-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20602679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J H Woods, F Medzihradsky, C B Smith, G Winger, J R Traynor
{"title":"Evaluation of new compounds for opioid activity (1997).","authors":"J H Woods, F Medzihradsky, C B Smith, G Winger, J R Traynor","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76229,"journal":{"name":"NIDA research monograph","volume":"178 ","pages":"408-28"},"PeriodicalIF":0.0,"publicationDate":"1998-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20602670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R E Tarter, H Moss, T Blackson, M Vanyukov, J Brigham, R Loeber
{"title":"Disaggregating the liability for drug abuse.","authors":"R E Tarter, H Moss, T Blackson, M Vanyukov, J Brigham, R Loeber","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76229,"journal":{"name":"NIDA research monograph","volume":"169 ","pages":"227-43"},"PeriodicalIF":0.0,"publicationDate":"1998-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20603759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号