{"title":"BODIPY衍生物作为活细胞分子活动的荧光报告者","authors":"V. Martynov, A. A. Pakhomov","doi":"10.1070/RCR4985","DOIUrl":null,"url":null,"abstract":"Fluorescent compounds have become indispensable tools for imaging molecular activities in the living cell. 4,4-Difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) is currently one of the most popular fluorescent reporters due to its unique photophysical properties. This review provides a general survey and presents a summary of recent advances in the development of new BODIPY-based cellular biomarkers and biosensors. The review starts with the consideration of the properties of BODIPY derivatives required for their application as cellular reporters. Then review provides examples of the design of sensors for different biologically important molecules, ions, membrane potential, temperature and viscosity defining the live cell status. Special attention is payed to BODPY-based phototransformable reporters. The bibliography includes 339 references.","PeriodicalId":21523,"journal":{"name":"Russian Chemical Reviews","volume":"90 1","pages":"1213 - 1262"},"PeriodicalIF":7.0000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"8","resultStr":"{\"title\":\"BODIPY derivatives as fluorescent reporters of molecular activities in living cells\",\"authors\":\"V. Martynov, A. A. Pakhomov\",\"doi\":\"10.1070/RCR4985\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Fluorescent compounds have become indispensable tools for imaging molecular activities in the living cell. 4,4-Difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) is currently one of the most popular fluorescent reporters due to its unique photophysical properties. This review provides a general survey and presents a summary of recent advances in the development of new BODIPY-based cellular biomarkers and biosensors. The review starts with the consideration of the properties of BODIPY derivatives required for their application as cellular reporters. Then review provides examples of the design of sensors for different biologically important molecules, ions, membrane potential, temperature and viscosity defining the live cell status. Special attention is payed to BODPY-based phototransformable reporters. The bibliography includes 339 references.\",\"PeriodicalId\":21523,\"journal\":{\"name\":\"Russian Chemical Reviews\",\"volume\":\"90 1\",\"pages\":\"1213 - 1262\"},\"PeriodicalIF\":7.0000,\"publicationDate\":\"2021-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"8\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Russian Chemical Reviews\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1070/RCR4985\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Chemical Reviews","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1070/RCR4985","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
BODIPY derivatives as fluorescent reporters of molecular activities in living cells
Fluorescent compounds have become indispensable tools for imaging molecular activities in the living cell. 4,4-Difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) is currently one of the most popular fluorescent reporters due to its unique photophysical properties. This review provides a general survey and presents a summary of recent advances in the development of new BODIPY-based cellular biomarkers and biosensors. The review starts with the consideration of the properties of BODIPY derivatives required for their application as cellular reporters. Then review provides examples of the design of sensors for different biologically important molecules, ions, membrane potential, temperature and viscosity defining the live cell status. Special attention is payed to BODPY-based phototransformable reporters. The bibliography includes 339 references.
期刊介绍：
Russian Chemical Reviews serves as a complete translation of the esteemed monthly review journal Uspekhi Khimii, which has been a prominent figure in Russian scientific journals since its establishment in 1932. It offers comprehensive access to the advancements made by chemists from Russia and other former Soviet Union countries.
Established in 1932, Russian Chemical Reviews is committed to publishing timely and significant review articles encompassing various facets of modern chemistry, including chemical physics, physical chemistry, computational and theoretical chemistry, catalysis, coordination chemistry, analytical chemistry, organic, organometallic, and organoelement chemistry, chemistry of macromolecules, applied chemistry, biochemistry, bio-organic chemistry, biomolecular chemistry, medicinal chemistry, materials chemistry, nanochemistry, nanostructures, and environmental chemistry.
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