{"title":"环氧乙烷:危害表征和暴露反应分析","authors":"R. Liteplo, M. E. Meek, W. Bruce","doi":"10.1081/GNC-100103586","DOIUrl":null,"url":null,"abstract":"Ethylene oxide has been assessed as a Priority Substance under the Canadian Environmental Protection Act. Based on studies in animals, cancer is considered the critical endpoint for effects of ethylene oxide on human health. In inhalation studies, ethylene oxide has induced a wide range of tumours, with a strong likelihood that the mode of action involves direct interaction with genetic material. Tumorigenic Concentration05s (i.e., concentrations associated with a 5% increase in tumour incidence above background), derived from a study in animals with optimal characterization of exposure–response, ranged from 2.2 to 31.0 mg/m3.","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":"19 1","pages":"219 - 265"},"PeriodicalIF":1.2000,"publicationDate":"2001-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1081/GNC-100103586","citationCount":"1","resultStr":"{\"title\":\"ETHYLENE OXIDE: HAZARD CHARACTERIZATION AND EXPOSURE–RESPONSE ANALYSIS\",\"authors\":\"R. Liteplo, M. E. Meek, W. Bruce\",\"doi\":\"10.1081/GNC-100103586\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Ethylene oxide has been assessed as a Priority Substance under the Canadian Environmental Protection Act. Based on studies in animals, cancer is considered the critical endpoint for effects of ethylene oxide on human health. In inhalation studies, ethylene oxide has induced a wide range of tumours, with a strong likelihood that the mode of action involves direct interaction with genetic material. Tumorigenic Concentration05s (i.e., concentrations associated with a 5% increase in tumour incidence above background), derived from a study in animals with optimal characterization of exposure–response, ranged from 2.2 to 31.0 mg/m3.\",\"PeriodicalId\":53200,\"journal\":{\"name\":\"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis\",\"volume\":\"19 1\",\"pages\":\"219 - 265\"},\"PeriodicalIF\":1.2000,\"publicationDate\":\"2001-05-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1081/GNC-100103586\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis\",\"FirstCategoryId\":\"93\",\"ListUrlMain\":\"https://doi.org/10.1081/GNC-100103586\",\"RegionNum\":4,\"RegionCategory\":\"环境科学与生态学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ENVIRONMENTAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","FirstCategoryId":"93","ListUrlMain":"https://doi.org/10.1081/GNC-100103586","RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
ETHYLENE OXIDE: HAZARD CHARACTERIZATION AND EXPOSURE–RESPONSE ANALYSIS
Ethylene oxide has been assessed as a Priority Substance under the Canadian Environmental Protection Act. Based on studies in animals, cancer is considered the critical endpoint for effects of ethylene oxide on human health. In inhalation studies, ethylene oxide has induced a wide range of tumours, with a strong likelihood that the mode of action involves direct interaction with genetic material. Tumorigenic Concentration05s (i.e., concentrations associated with a 5% increase in tumour incidence above background), derived from a study in animals with optimal characterization of exposure–response, ranged from 2.2 to 31.0 mg/m3.
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