钯催化的[4+2]羟基系链碳酸烯烯酯与烯烃的环加成:功能化四氢吡喃的合成

IF 4.4 2区化学 Q2 CHEMISTRY, APPLIED Advanced Synthesis & Catalysis Pub Date : 2022-06-21 DOI:10.1002/adsc.202200160

Jiaqing Xu , Wangyu Shi , Min Liu , Jianning Liao , Wei Wang , Yongjun Wu , Hongchao Guo

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引用次数: 7

摘要

钯催化[4+2]羰基烯丙酯与五种缺电子烯烃的环加成，其中一种新的羰基烯丙酯作为形成1,4 - C,O -偶极烯丙基钯中间体的有价值的前体。该反应在温和的反应条件下进行，得到了相应的中高收率的四氢吡喃衍生物，具有优异的非对映选择性。

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Palladium‐Catalyzed [4+2] Cycloaddition of Hydroxy‐Tethered Allylic Carbonates with Alkenes: Synthesis of Functionalized Tetrahydropyrans

A palladium‐catalyzed [4+2] cycloaddition of hydroxy‐tethered allyl carbonates with five types of electron‐deficient alkenes has been achieved, in which a type of new hydroxy‐tethered allyl carbonates acted as valuable precursors for the formation of 1,4‐C,O‐dipole allylpalladium intermediates. The reaction proceeded efficiently under mild reaction conditions to provide the corresponding tetrahydropyran derivatives in moderate to high yields with excellent diastereoselectivities.

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.