{"title":"急性吗啡给药对脑儿茶酚胺代谢的影响。","authors":"H. Loh, R. Hitzemann, E. Way","doi":"10.1097/00132586-197402000-00015","DOIUrl":null,"url":null,"abstract":"Abstract The effects of sub-analgetic and analgetic doses of morphine (5–20 mg/kg) on the metabolism of intravenously administered [ 14 C]-tyrosine (200 uCi/kg) in the mouse brain were investigated. A significantly increased conversion of [ 14 C]-tyrosine to the [ 14 C]-catecholamines was observed only at an analgetic dose of morphine. Furthermore, morphine increased the specific activity of brain [ 14 C]-tyrosine and this effect was blocked by naloxone, a morphine antagonist.","PeriodicalId":78415,"journal":{"name":"Life sciences. Pt. 1: Physiology and pharmacology","volume":"12 1 1","pages":"33-41"},"PeriodicalIF":0.0000,"publicationDate":"1973-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/00132586-197402000-00015","citationCount":"35","resultStr":"{\"title\":\"Effect of acute morphine administration on the metabolism of brain catecholamines.\",\"authors\":\"H. Loh, R. Hitzemann, E. Way\",\"doi\":\"10.1097/00132586-197402000-00015\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Abstract The effects of sub-analgetic and analgetic doses of morphine (5–20 mg/kg) on the metabolism of intravenously administered [ 14 C]-tyrosine (200 uCi/kg) in the mouse brain were investigated. A significantly increased conversion of [ 14 C]-tyrosine to the [ 14 C]-catecholamines was observed only at an analgetic dose of morphine. Furthermore, morphine increased the specific activity of brain [ 14 C]-tyrosine and this effect was blocked by naloxone, a morphine antagonist.\",\"PeriodicalId\":78415,\"journal\":{\"name\":\"Life sciences. Pt. 1: Physiology and pharmacology\",\"volume\":\"12 1 1\",\"pages\":\"33-41\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1973-01-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1097/00132586-197402000-00015\",\"citationCount\":\"35\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Life sciences. Pt. 1: Physiology and pharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1097/00132586-197402000-00015\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Life sciences. Pt. 1: Physiology and pharmacology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/00132586-197402000-00015","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effect of acute morphine administration on the metabolism of brain catecholamines.
Abstract The effects of sub-analgetic and analgetic doses of morphine (5–20 mg/kg) on the metabolism of intravenously administered [ 14 C]-tyrosine (200 uCi/kg) in the mouse brain were investigated. A significantly increased conversion of [ 14 C]-tyrosine to the [ 14 C]-catecholamines was observed only at an analgetic dose of morphine. Furthermore, morphine increased the specific activity of brain [ 14 C]-tyrosine and this effect was blocked by naloxone, a morphine antagonist.
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