一种用于本体感觉假体的节能、动态电压缩放神经刺激器

IF 3.8 2区 医学 Q2 ENGINEERING, BIOMEDICAL IEEE Transactions on Biomedical Circuits and Systems Pub Date : 2012-05-20 DOI:10.1109/ISCAS.2012.6271420
I. Williams, T. Constandinou
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引用次数: 95

摘要

提出了一种用于产生电荷平衡非对称脉冲的8通道节能神经刺激器。通过实现完全集成的DC-DC转换器,降低功耗,该转换器使用可重构开关电容拓扑,为动态电压缩放(DVS)提供4个输出电压。使用小于1nf的集成电容,可实现高达82%的直流转换效率,与典型的电流控制神经刺激器前端相比,DVS方法可节省高达50%的功率。实现了一种新颖的电荷平衡方法,该方法在单脉冲上具有较低的精度,而在一系列脉冲上具有较高的精度。所使用的方法对工艺和成分变化具有鲁棒性,不需要任何初始或持续校准。测量结果表明,对于一系列脉冲,电荷不平衡通常在注入电荷的0.05% ~ 0.15%之间。离体实验证明了利用该回路进行神经激活的可行性。该电路采用商用0.18 μm HV CMOS技术实现,核心芯片面积约为2.8 mm2,实现8通道。
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An Energy-Efficient, Dynamic Voltage Scaling Neural Stimulator for a Proprioceptive Prosthesis
This paper presents an 8 channel energy-efficient neural stimulator for generating charge-balanced asymmetric pulses. Power consumption is reduced by implementing a fully-integrated DC-DC converter that uses a reconfigurable switched capacitor topology to provide 4 output voltages for Dynamic Voltage Scaling (DVS). DC conversion efficiencies of up to 82% are achieved using integrated capacitances of under 1 nF and the DVS approach offers power savings of up to 50% compared to the front end of a typical current controlled neural stimulator. A novel charge balancing method is implemented which has a low level of accuracy on a single pulse and a much higher accuracy over a series of pulses. The method used is robust to process and component variation and does not require any initial or ongoing calibration. Measured results indicate that the charge imbalance is typically between 0.05%-0.15% of charge injected for a series of pulses. Ex-vivo experiments demonstrate the viability in using this circuit for neural activation. The circuit has been implemented in a commercially-available 0.18 μm HV CMOS technology and occupies a core die area of approximately 2.8 mm2 for an 8 channel implementation.
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来源期刊
IEEE Transactions on Biomedical Circuits and Systems
IEEE Transactions on Biomedical Circuits and Systems 工程技术-工程:电子与电气
CiteScore
10.00
自引率
13.70%
发文量
174
审稿时长
3 months
期刊介绍: The IEEE Transactions on Biomedical Circuits and Systems addresses areas at the crossroads of Circuits and Systems and Life Sciences. The main emphasis is on microelectronic issues in a wide range of applications found in life sciences, physical sciences and engineering. The primary goal of the journal is to bridge the unique scientific and technical activities of the Circuits and Systems Society to a wide variety of related areas such as: • Bioelectronics • Implantable and wearable electronics like cochlear and retinal prosthesis, motor control, etc. • Biotechnology sensor circuits, integrated systems, and networks • Micropower imaging technology • BioMEMS • Lab-on-chip Bio-nanotechnology • Organic Semiconductors • Biomedical Engineering • Genomics and Proteomics • Neuromorphic Engineering • Smart sensors • Low power micro- and nanoelectronics • Mixed-mode system-on-chip • Wireless technology • Gene circuits and molecular circuits • System biology • Brain science and engineering: such as neuro-informatics, neural prosthesis, cognitive engineering, brain computer interface • Healthcare: information technology for biomedical, epidemiology, and other related life science applications. General, theoretical, and application-oriented papers in the abovementioned technical areas with a Circuits and Systems perspective are encouraged to publish in TBioCAS. Of special interest are biomedical-oriented papers with a Circuits and Systems angle.
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