从嗜热菌中结晶的蛋白质揭示转录的见解

Microbe (Washington, D.C.) Pub Date : 2016-09-01 DOI:10.1128/MICROBE.11.377.1

C. Potera

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引用次数: 0

摘要

最近确定的细菌II类转录复合体的三维(3D)结构有助于揭示它如何结合特定的DNA序列，从而驱动下游基因的转录。新泽西州皮斯卡塔威罗格斯大学的Richard H. Ebright和他的同事在2016年6月10日的《科学》杂志上报告了他们的发现(doi:10.1126/ Science .aaf4417)，这种基于x射线的结构分析为这种完整的II类转录激活复合物提供了第一个原子结构。

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Crystalized Proteins from Thermophile Reveal Transcription Insights

The recently determined three-dimensional (3D) structure of a bacterial class II transcription complex helps to reveal how it binds to specific DNA sequences, thus driving transcription of downstream genes. This X-ray-based structural analysis provides the first atomic structure for such an intact class II transcription activation complex, according to Richard H. Ebright at Rutgers University in Piscataway, N.J. He and his colleagues reported their findings on 10 June 2016 in Science (doi:10.1126/science.aaf4417).

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Microbe (Washington, D.C.)

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