电刺激大髓鞘传入神经抑制大鼠脊髓背角神经元对有害和无害皮肤刺激的反应

M. Tsuruoka, Yong-ning Wang, Y. Matsui
{"title":"电刺激大髓鞘传入神经抑制大鼠脊髓背角神经元对有害和无害皮肤刺激的反应","authors":"M. Tsuruoka, Yong-ning Wang, Y. Matsui","doi":"10.11516/DENTALMEDRES1981.13.31","DOIUrl":null,"url":null,"abstract":"The inhibitory effects of electrical stimulation of large myelinated afferents on_ spinal dorsal horn neurons were investigated. In rats anesthetized with thiamylal sodium,_ responses of 153 dorsal horn neurons to noxious heating or innocuous mechanical stimulation_ (light brushing) of the tail were recorded from the sacral and coccygeal levels of the spinal cord_ by extracellular microelectrodes. Of these neurons, 45 were low-threshold mechanoreceptive_ (LTM), 47 were nociceptive-specific (NS), and 61 were wide-dynamic-range (WDR) neurons_. In 22.2% of the LTM neurons, responses to innocuous mechanical stimulation were inhibited_ by electrical stimulation of large myelinated afferents applied to the ipsilateral hindlimb for_ 5 min. This conditioning stimulation (large myelinated afferent stimulation, LMAS) also inhibited noxious heat responses in 19.2% of the NS neurons. The inhibitory effect of LMAS_ on WDR neurons was nonselective in that both responses to light brushing and noxious heating were inhibited. Of the WDR neurons, 27.3 % were inhibited by LMAS. These results_ indicate that inhibition produced by LMAS is exerted on all 3 classes of spinal dorsal horn neu_ rons.","PeriodicalId":77624,"journal":{"name":"Showa Shigakkai zasshi = The Journal of Showa University Dental Society","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1993-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Electrical Stimulation of Large Myelinated Afferents Inhibits Responses of Rat Spinal Dorsal Horn Neurons to Noxious and Innocuous Cutaneous Stimulation\",\"authors\":\"M. Tsuruoka, Yong-ning Wang, Y. Matsui\",\"doi\":\"10.11516/DENTALMEDRES1981.13.31\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The inhibitory effects of electrical stimulation of large myelinated afferents on_ spinal dorsal horn neurons were investigated. In rats anesthetized with thiamylal sodium,_ responses of 153 dorsal horn neurons to noxious heating or innocuous mechanical stimulation_ (light brushing) of the tail were recorded from the sacral and coccygeal levels of the spinal cord_ by extracellular microelectrodes. Of these neurons, 45 were low-threshold mechanoreceptive_ (LTM), 47 were nociceptive-specific (NS), and 61 were wide-dynamic-range (WDR) neurons_. In 22.2% of the LTM neurons, responses to innocuous mechanical stimulation were inhibited_ by electrical stimulation of large myelinated afferents applied to the ipsilateral hindlimb for_ 5 min. This conditioning stimulation (large myelinated afferent stimulation, LMAS) also inhibited noxious heat responses in 19.2% of the NS neurons. The inhibitory effect of LMAS_ on WDR neurons was nonselective in that both responses to light brushing and noxious heating were inhibited. Of the WDR neurons, 27.3 % were inhibited by LMAS. These results_ indicate that inhibition produced by LMAS is exerted on all 3 classes of spinal dorsal horn neu_ rons.\",\"PeriodicalId\":77624,\"journal\":{\"name\":\"Showa Shigakkai zasshi = The Journal of Showa University Dental Society\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1993-03-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Showa Shigakkai zasshi = The Journal of Showa University Dental Society\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.11516/DENTALMEDRES1981.13.31\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Showa Shigakkai zasshi = The Journal of Showa University Dental Society","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.11516/DENTALMEDRES1981.13.31","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1

摘要

研究了电刺激大髓鞘传入神经对脊髓背角神经元的抑制作用。用细胞外微电极记录了经硫胺钠麻醉的大鼠153个背角神经元对尾巴的有害加热或无害机械刺激(轻刷)的反应。在这些神经元中,45个是低阈值机械感受性神经元,47个是伤害特异性神经元,61个是宽动态范围神经元。在22.2%的LTM神经元中,对无害机械刺激的反应被施加于同侧后肢的大髓鞘传入神经5分钟的电刺激所抑制。这种条件刺激(大髓鞘传入神经刺激,LMAS)也抑制了19.2%的NS神经元的有害热反应。LMAS_对WDR神经元的抑制作用是非选择性的,对光刷和有害加热的反应均被抑制。在WDR神经元中,27.3%被LMAS抑制。这些结果表明LMAS对脊髓背角3类神经元均有抑制作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Electrical Stimulation of Large Myelinated Afferents Inhibits Responses of Rat Spinal Dorsal Horn Neurons to Noxious and Innocuous Cutaneous Stimulation
The inhibitory effects of electrical stimulation of large myelinated afferents on_ spinal dorsal horn neurons were investigated. In rats anesthetized with thiamylal sodium,_ responses of 153 dorsal horn neurons to noxious heating or innocuous mechanical stimulation_ (light brushing) of the tail were recorded from the sacral and coccygeal levels of the spinal cord_ by extracellular microelectrodes. Of these neurons, 45 were low-threshold mechanoreceptive_ (LTM), 47 were nociceptive-specific (NS), and 61 were wide-dynamic-range (WDR) neurons_. In 22.2% of the LTM neurons, responses to innocuous mechanical stimulation were inhibited_ by electrical stimulation of large myelinated afferents applied to the ipsilateral hindlimb for_ 5 min. This conditioning stimulation (large myelinated afferent stimulation, LMAS) also inhibited noxious heat responses in 19.2% of the NS neurons. The inhibitory effect of LMAS_ on WDR neurons was nonselective in that both responses to light brushing and noxious heating were inhibited. Of the WDR neurons, 27.3 % were inhibited by LMAS. These results_ indicate that inhibition produced by LMAS is exerted on all 3 classes of spinal dorsal horn neu_ rons.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
術前顎矯正治療(NAM)が哺乳へ与える影響について 裂型別にみる哺乳障害の現状アンケート調査 SEM and TEM Observation of Ultra Microstructure at Adhesive Interface between Resin and Caries Affected Dentin Suppression of Visceromotor Function Induced by Noxious Stimulation to the Oral-facial Region in the Rat Noggin Prevents Osteogenesis but Induces Chondrogenesis in a Human Mesenchymal Cell Line (USAC) Electromyographic Evaluation of Masticatory Muscles Following Surgical Orthodontics with Skeletal Mandibular Prognathism
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1