Pub Date : 2007-09-30DOI: 10.11516/DENTALMEDRES1981.27.173
Takeaki Endo, M. Kusunoki, K. Itoh, T. Tachikawa, Misa Oikawa, C. Tani, H. Hisamitsu
To prevent over-cutting of the sclerotic dentin, we developed a new caries detector (Caries Check, Nippon Shika Yakuhin Co., Ltd., Japan) composed of polypropylene glycol containing acid red. The purpose of this study was to observe the ultra microstructure of the adhesive interface between resin composite and dentin after cutting the dentin in accordance with the conventional Caries Detector or Caries Check staining. In the Caries Check specimen, the dentin tubules were filled with debris and penetration of the bonding agent was limited in the peri-tubular dentin. In the Caries Detector specimen, the dentin tubules were open and a resin tag formed in the dentin tubules. It was possible to conclude that the sclerotic dentin was preserved under the guide of staining by Caries Check. The results suggest that dentin bonding was not obtained by monomer penetration into the superficial substrate dentin or into the dentin tubules.
{"title":"SEM and TEM Observation of Ultra Microstructure at Adhesive Interface between Resin and Caries Affected Dentin","authors":"Takeaki Endo, M. Kusunoki, K. Itoh, T. Tachikawa, Misa Oikawa, C. Tani, H. Hisamitsu","doi":"10.11516/DENTALMEDRES1981.27.173","DOIUrl":"https://doi.org/10.11516/DENTALMEDRES1981.27.173","url":null,"abstract":"To prevent over-cutting of the sclerotic dentin, we developed a new caries detector (Caries Check, Nippon Shika Yakuhin Co., Ltd., Japan) composed of polypropylene glycol containing acid red. The purpose of this study was to observe the ultra microstructure of the adhesive interface between resin composite and dentin after cutting the dentin in accordance with the conventional Caries Detector or Caries Check staining. In the Caries Check specimen, the dentin tubules were filled with debris and penetration of the bonding agent was limited in the peri-tubular dentin. In the Caries Detector specimen, the dentin tubules were open and a resin tag formed in the dentin tubules. It was possible to conclude that the sclerotic dentin was preserved under the guide of staining by Caries Check. The results suggest that dentin bonding was not obtained by monomer penetration into the superficial substrate dentin or into the dentin tubules.","PeriodicalId":77624,"journal":{"name":"Showa Shigakkai zasshi = The Journal of Showa University Dental Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2007-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.11516/DENTALMEDRES1981.27.173","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64476835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2007-09-30DOI: 10.11516/DENTALMEDRES1981.27.181
B. Hayashi, M. Tsuruoka, M. Maeda, Liming Liu, Tomio Inoue
{"title":"Suppression of Visceromotor Function Induced by Noxious Stimulation to the Oral-facial Region in the Rat","authors":"B. Hayashi, M. Tsuruoka, M. Maeda, Liming Liu, Tomio Inoue","doi":"10.11516/DENTALMEDRES1981.27.181","DOIUrl":"https://doi.org/10.11516/DENTALMEDRES1981.27.181","url":null,"abstract":"","PeriodicalId":77624,"journal":{"name":"Showa Shigakkai zasshi = The Journal of Showa University Dental Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2007-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64476983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2007-06-30DOI: 10.11516/DENTALMEDRES1981.27.124
Y. Yoshizawa, K. Yagami, Yohei Uyama, S. Kakuta, M. Nagumo
The differentiation of mesenchymal stem cells (MSCs) into chondrocytes and osteoblasts is minutely regulated by bone morphogenetic proteins (BMPs) and various factors . There is no study describing the role of noggin in the differentiation from MSCs to chondrocytes or osteoblasts. We thus examined the effect of noggin onchondrogenesis and osteogenesis in a human cell line that expresses chondrocytic phenotypes, and the role of noggin in these processes . Noggin induces chondrogenic differentiation, and its repression induces osteogenic differentiation through BMP effects. Noggin is reported to bind several BMPs and to inhibit their functions, but its exact role is not yet clarified. USAC cells usually show chondrogenic phenotypes and also have the potential to differentiate into osteoblasts and adipocytes under somecircumstances . We investigated the effects of noggin on chondrogenic and osteogenic differentiationof USAC cells in vitro and in vivo. After USAC cells were treated with noggin antisense oligonucleotide (As-Noggin) or noggin protein (rhNoggin), RT-PCR was performed to detect mRNAsof type I collagen (Col I), type II collagen (Col II), Cbfal, aggrecan (AG), Sox9 and osteocalcin (OC) on days 3, 7 and 14. Western blot analysis was done to detect Col II, BMP-2, BMP-4, Cbfal and OC proteins . Toluidine blue staining and immunostaining for Col II, BMP-2 , Cbfal andOC were also performed. As-Noggin induced the up-regulation of Col I and OC mRNAexpression in USAC cells time-dependently, while it down-regulated the expressionof Col II and AG mRNAs . As-Noggin stimulated BMP-2, Cbfal and OC production, but it reduced the production of Col II and BMP-4 . Moreover, OC mRNA expression and BMP-2 production were down-regulated by the addition of rhNoggin. The same results were obtained by immunostaining. These results suggest that noggin may regulate chondrogenic and osteogenic differentiation through the production of BMP-2 and BMP-4.
{"title":"Noggin Prevents Osteogenesis but Induces Chondrogenesis in a Human Mesenchymal Cell Line (USAC)","authors":"Y. Yoshizawa, K. Yagami, Yohei Uyama, S. Kakuta, M. Nagumo","doi":"10.11516/DENTALMEDRES1981.27.124","DOIUrl":"https://doi.org/10.11516/DENTALMEDRES1981.27.124","url":null,"abstract":"The differentiation of mesenchymal stem cells (MSCs) into chondrocytes and osteoblasts is minutely regulated by bone morphogenetic proteins (BMPs) and various factors . There is no study describing the role of noggin in the differentiation from MSCs to chondrocytes or osteoblasts. We thus examined the effect of noggin onchondrogenesis and osteogenesis in a human cell line that expresses chondrocytic phenotypes, and the role of noggin in these processes . Noggin induces chondrogenic differentiation, and its repression induces osteogenic differentiation through BMP effects. Noggin is reported to bind several BMPs and to inhibit their functions, but its exact role is not yet clarified. USAC cells usually show chondrogenic phenotypes and also have the potential to differentiate into osteoblasts and adipocytes under somecircumstances . We investigated the effects of noggin on chondrogenic and osteogenic differentiationof USAC cells in vitro and in vivo. After USAC cells were treated with noggin antisense oligonucleotide (As-Noggin) or noggin protein (rhNoggin), RT-PCR was performed to detect mRNAsof type I collagen (Col I), type II collagen (Col II), Cbfal, aggrecan (AG), Sox9 and osteocalcin (OC) on days 3, 7 and 14. Western blot analysis was done to detect Col II, BMP-2, BMP-4, Cbfal and OC proteins . Toluidine blue staining and immunostaining for Col II, BMP-2 , Cbfal andOC were also performed. As-Noggin induced the up-regulation of Col I and OC mRNAexpression in USAC cells time-dependently, while it down-regulated the expressionof Col II and AG mRNAs . As-Noggin stimulated BMP-2, Cbfal and OC production, but it reduced the production of Col II and BMP-4 . Moreover, OC mRNA expression and BMP-2 production were down-regulated by the addition of rhNoggin. The same results were obtained by immunostaining. These results suggest that noggin may regulate chondrogenic and osteogenic differentiation through the production of BMP-2 and BMP-4.","PeriodicalId":77624,"journal":{"name":"Showa Shigakkai zasshi = The Journal of Showa University Dental Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2007-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.11516/DENTALMEDRES1981.27.124","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64476713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2007-03-31DOI: 10.11516/DENTALMEDRES1981.27.16
Hiroyuki Watanabe, Tetsutaro Yamaguchi, K. Nakajima, Toshirou Usui, S. Shintani, T. Shirota, M. Ohashi, K. Maki
{"title":"Electromyographic Evaluation of Masticatory Muscles Following Surgical Orthodontics with Skeletal Mandibular Prognathism","authors":"Hiroyuki Watanabe, Tetsutaro Yamaguchi, K. Nakajima, Toshirou Usui, S. Shintani, T. Shirota, M. Ohashi, K. Maki","doi":"10.11516/DENTALMEDRES1981.27.16","DOIUrl":"https://doi.org/10.11516/DENTALMEDRES1981.27.16","url":null,"abstract":"","PeriodicalId":77624,"journal":{"name":"Showa Shigakkai zasshi = The Journal of Showa University Dental Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2007-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64476815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2006-03-31DOI: 10.11516/DENTALMEDRES1981.26.1
Makio Nagano, H. Sakamaki, K. Yagami, S. Kakuta, M. Nagumo
Gap junctions are associated with cell growth and differentiation i tissue organization. However, the association of gap junctions with chondrogenesis or chondrogenic differentiation isstill unclear. We succeeded in establishing a cartilaginous transplanted tumor in a nude mouse from a human chondroblastic osteosarcoma, nd a cell line (USAC) expressing chondrocytic phenotypes from the transplanted tumor. Using these transplanted tumor and USAC cells, we investigated the relationship between the expression of gap junctions and chondrogenesis or chondrogenic differentiation. Gap junctions are observed by immunostaining with connexin 43 (Cx 43) protein, which is an intrinsic component of gap junctions. The results revealed that Cx 43 in the tumor tissue was found both on chondrocytic and hypertrophic ells. In cultured cells, gap junctions composed of Cx 43 appearing as USAC cells were condensed and progressed toward mature chondrocytic ells. A high density micro-mass culture of USAC cells showed that dexamethasone and 1 a, 25 (OH)21)3, which stimulated chondrogenic differentiation, enhanced the expression of Cx 43. These results indicate that expression of gap junctions is closely linked to chondrogenesis and chondrogenic differentiation.
{"title":"Relationship between the Expression of Connexin 43 and Chondrogenic Differentiation in a Cartilaginous Transplanted Tumor and a Chondrocytic Cell Line","authors":"Makio Nagano, H. Sakamaki, K. Yagami, S. Kakuta, M. Nagumo","doi":"10.11516/DENTALMEDRES1981.26.1","DOIUrl":"https://doi.org/10.11516/DENTALMEDRES1981.26.1","url":null,"abstract":"Gap junctions are associated with cell growth and differentiation i tissue organization. However, the association of gap junctions with chondrogenesis or chondrogenic differentiation isstill unclear. We succeeded in establishing a cartilaginous transplanted tumor in a nude mouse from a human chondroblastic osteosarcoma, nd a cell line (USAC) expressing chondrocytic phenotypes from the transplanted tumor. Using these transplanted tumor and USAC cells, we investigated the relationship between the expression of gap junctions and chondrogenesis or chondrogenic differentiation. Gap junctions are observed by immunostaining with connexin 43 (Cx 43) protein, which is an intrinsic component of gap junctions. The results revealed that Cx 43 in the tumor tissue was found both on chondrocytic and hypertrophic ells. In cultured cells, gap junctions composed of Cx 43 appearing as USAC cells were condensed and progressed toward mature chondrocytic ells. A high density micro-mass culture of USAC cells showed that dexamethasone and 1 a, 25 (OH)21)3, which stimulated chondrogenic differentiation, enhanced the expression of Cx 43. These results indicate that expression of gap junctions is closely linked to chondrogenesis and chondrogenic differentiation.","PeriodicalId":77624,"journal":{"name":"Showa Shigakkai zasshi = The Journal of Showa University Dental Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2006-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64477063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2006-03-31DOI: 10.11516/DENTALMEDRES1981.26.9
S. Yoshida, T. Aida, T. Tachikawa
Lymphatic vessels are distributed directly under the epithelium of the oral mucosal. In the present study, we investigated whether lymphoangiogenseis in tumors occurs in human oral squamous cell carcinoma and whether the density of tumor lympahngiogensis may be related to the risk of lymph node metastasis. Moreover, these analyses identified peritumoral lymphatic vascular density as a novel prognostic indicator for the risk of lymph node metastasis in oral squamous cell carcinoma. LYVE-1, which was an endothelial cell hyaluronic acid receptor, has been identified as a peculiar protein of endothelial cells of lymphatic vessels. LYVE-1 expression in the carcinoma tissue was divided into two types. In one it appears in contact with the cancer nest. This shows contact with basal-like cells which are located on the outer side of the cancer nest, and observation via light microscope is unable to show intervention of the fibrous connective tissues. The other case is that in which there is intervention of the clear fibrous connective tissues between the cancer nest and LYVE-1-positive cells. The cancer cells showed a high degree of differentiation, increased by the formation of the cancer nest, and in what is called highly-differentiated squamous cell carcinoma whose invasion pattern showed INF alpha, the cells staining positive to the LYVE-1 antibody could be recognized only negligibly in the connective tissue. Positive staining of the LYVE-1 antibody was seen in the endothelial cells presenting in the lumen formed between each small cancer nest in the case of undifferentiated squamous cell carcinoma in which the cancer nest was very small and composed of undifferentiated cancer cells. In this case the cancer invasion pattern shows INFy. In addition, the expression of LYVE-1 was recognized in cells which had not formed into the lumen between the cancer nests. In the meantime, VEGF-C was expressed in endothelial cells which formed the lumen and cancer cells. In the cancer cells which formed the large cancer nest, the expression of VEGF-C was recognized in basal-like cells which located at the periphery of the nest. VEGF-C was expressed in the cancer cells which formed the small nest. The results of this study show that the incidence of VEGF-C expression in the cancer cell is low. However, lymphatic vessels form in carcinoma tissue at a high rate when VEGF-C is expressed. It was shown that in this study, the close proximity of the lymphatic vessel to the cancer nest shows correlation to lymph node metastasis. This should affect the determination of the operation range, and have a direct influence on prognosis. It is also indicated that LYVE-1 can act as a useful marker in oral cancer.
{"title":"Lymphatic Vessel Density and Lymphangiogenesis in Human Oral Squamous Cell Carcinoma","authors":"S. Yoshida, T. Aida, T. Tachikawa","doi":"10.11516/DENTALMEDRES1981.26.9","DOIUrl":"https://doi.org/10.11516/DENTALMEDRES1981.26.9","url":null,"abstract":"Lymphatic vessels are distributed directly under the epithelium of the oral mucosal. In the present study, we investigated whether lymphoangiogenseis in tumors occurs in human oral squamous cell carcinoma and whether the density of tumor lympahngiogensis may be related to the risk of lymph node metastasis. Moreover, these analyses identified peritumoral lymphatic vascular density as a novel prognostic indicator for the risk of lymph node metastasis in oral squamous cell carcinoma. LYVE-1, which was an endothelial cell hyaluronic acid receptor, has been identified as a peculiar protein of endothelial cells of lymphatic vessels. LYVE-1 expression in the carcinoma tissue was divided into two types. In one it appears in contact with the cancer nest. This shows contact with basal-like cells which are located on the outer side of the cancer nest, and observation via light microscope is unable to show intervention of the fibrous connective tissues. The other case is that in which there is intervention of the clear fibrous connective tissues between the cancer nest and LYVE-1-positive cells. The cancer cells showed a high degree of differentiation, increased by the formation of the cancer nest, and in what is called highly-differentiated squamous cell carcinoma whose invasion pattern showed INF alpha, the cells staining positive to the LYVE-1 antibody could be recognized only negligibly in the connective tissue. Positive staining of the LYVE-1 antibody was seen in the endothelial cells presenting in the lumen formed between each small cancer nest in the case of undifferentiated squamous cell carcinoma in which the cancer nest was very small and composed of undifferentiated cancer cells. In this case the cancer invasion pattern shows INFy. In addition, the expression of LYVE-1 was recognized in cells which had not formed into the lumen between the cancer nests. In the meantime, VEGF-C was expressed in endothelial cells which formed the lumen and cancer cells. In the cancer cells which formed the large cancer nest, the expression of VEGF-C was recognized in basal-like cells which located at the periphery of the nest. VEGF-C was expressed in the cancer cells which formed the small nest. The results of this study show that the incidence of VEGF-C expression in the cancer cell is low. However, lymphatic vessels form in carcinoma tissue at a high rate when VEGF-C is expressed. It was shown that in this study, the close proximity of the lymphatic vessel to the cancer nest shows correlation to lymph node metastasis. This should affect the determination of the operation range, and have a direct influence on prognosis. It is also indicated that LYVE-1 can act as a useful marker in oral cancer.","PeriodicalId":77624,"journal":{"name":"Showa Shigakkai zasshi = The Journal of Showa University Dental Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2006-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.11516/DENTALMEDRES1981.26.9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64476654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2005-12-31DOI: 10.11516/DENTALMEDRES1981.25.257
M. Uddin, Masanori Nakamura, T. Okano, Sk. Farid Uddin Akter, S. Kondo, K. Nakajima
{"title":"Pattern of Oro-dental Problems and Knowledge Regarding Dental Care Practices among the Patients Attending Out Patient Department of a Selected Dental College Hospital in Dhaka, Bangladesh","authors":"M. Uddin, Masanori Nakamura, T. Okano, Sk. Farid Uddin Akter, S. Kondo, K. Nakajima","doi":"10.11516/DENTALMEDRES1981.25.257","DOIUrl":"https://doi.org/10.11516/DENTALMEDRES1981.25.257","url":null,"abstract":"","PeriodicalId":77624,"journal":{"name":"Showa Shigakkai zasshi = The Journal of Showa University Dental Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2005-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64476970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2005-12-31DOI: 10.11516/DENTALMEDRES1981.25.267
Shahin Hossain, Koukichi Matsumoto, J. Kinoshita, Y. Kimura, Shamsul Alam, Yukiko Takamatsu
The aims of this study were to compare the effectiveness of FlexMaster® nickeltitanium rotary and K-Flexofile® hand instruments with regard to straightening of curved root canals and preparation time, and to evaluate the morphological aspects of instrumented root canal walls in extracted human teeth. A total of 60 root canals in molar teeth, with curvatures ranging between 0 and 35°, were divided into three groups of 20 root canals each, based on the degree of curvature. Half of each group was prepared using FlexMaster® instruments by a crown-down preparation technique and the other half using K-Flexofile® by a conventional technique. After each instrumentation, the root canals were flushed with 3 ml of 5.25% sodium hypochlorite and 3% hydrogen peroxide, alternatively, and 1 ml of 14% EDTA. Using radiographs taken before and after root canal preparation, the angles of root canal curvature of all specimens were determined. The preparation time was also recorded. All roots were bisected longitudinally and the canal walls were examined by scanning electron microscopy for morphological aspects. The use of FlexMaster® instruments resulted in significantly less straightening of root canal curvatures and a shorter preparation time compared to K-Flexofiles® (p <0.01) . They resulted in less debris, but left a thicker smear layer at the apical third of root canal than the K-Flexofile®. These results showed that rapid preparation of curved root canals with minimal canal straightening was possible using FlexMaster® instruments, and the use of FlexMaster® resulted in less debris, but a thicker smear layer than that of K-Flexofile®.
{"title":"A Comparative Study of the Efficiency of FlexMaster ® NiTi Rotary and K-Flexofile ® Stainless Steel Hand Instruments","authors":"Shahin Hossain, Koukichi Matsumoto, J. Kinoshita, Y. Kimura, Shamsul Alam, Yukiko Takamatsu","doi":"10.11516/DENTALMEDRES1981.25.267","DOIUrl":"https://doi.org/10.11516/DENTALMEDRES1981.25.267","url":null,"abstract":"The aims of this study were to compare the effectiveness of FlexMaster® nickeltitanium rotary and K-Flexofile® hand instruments with regard to straightening of curved root canals and preparation time, and to evaluate the morphological aspects of instrumented root canal walls in extracted human teeth. A total of 60 root canals in molar teeth, with curvatures ranging between 0 and 35°, were divided into three groups of 20 root canals each, based on the degree of curvature. Half of each group was prepared using FlexMaster® instruments by a crown-down preparation technique and the other half using K-Flexofile® by a conventional technique. After each instrumentation, the root canals were flushed with 3 ml of 5.25% sodium hypochlorite and 3% hydrogen peroxide, alternatively, and 1 ml of 14% EDTA. Using radiographs taken before and after root canal preparation, the angles of root canal curvature of all specimens were determined. The preparation time was also recorded. All roots were bisected longitudinally and the canal walls were examined by scanning electron microscopy for morphological aspects. The use of FlexMaster® instruments resulted in significantly less straightening of root canal curvatures and a shorter preparation time compared to K-Flexofiles® (p <0.01) . They resulted in less debris, but left a thicker smear layer at the apical third of root canal than the K-Flexofile®. These results showed that rapid preparation of curved root canals with minimal canal straightening was possible using FlexMaster® instruments, and the use of FlexMaster® resulted in less debris, but a thicker smear layer than that of K-Flexofile®.","PeriodicalId":77624,"journal":{"name":"Showa Shigakkai zasshi = The Journal of Showa University Dental Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2005-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64477006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2005-09-30DOI: 10.11516/DENTALMEDRES1981.25.161
H. Morisaki, Kaeko Kurihara, Y. Haseba, Masakazu Takahashi, T. Igarashi
{"title":"The Cytolethal Distending Toxin of Actinobacillus actinomycetemcomitans Activates p53-dependent DNA Damage Checkpoint Pathways in Normal Human Fibroblasts","authors":"H. Morisaki, Kaeko Kurihara, Y. Haseba, Masakazu Takahashi, T. Igarashi","doi":"10.11516/DENTALMEDRES1981.25.161","DOIUrl":"https://doi.org/10.11516/DENTALMEDRES1981.25.161","url":null,"abstract":"","PeriodicalId":77624,"journal":{"name":"Showa Shigakkai zasshi = The Journal of Showa University Dental Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2005-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64476915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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