J P Pandey, G S Cooper, E L Treadwell, G S Gilkeson, E W St Clair, M A Dooley
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引用次数: 0
摘要
在一些研究中,免疫球蛋白γ(GM)链和卡帕(KM)链的遗传变异与系统性红斑狼疮(SLE)有关。然而,这些数据相互矛盾,只有一项研究考察了非裔美国人的相关性。我们在一项以人群为基础的系统性红斑狼疮病例对照研究中按种族检测了 GM 和 KM 所有型。通过血凝抑制法对患者(n = 222)和对照组(n = 273)的血清进行了 GM 和 KM 所有型的分型。在非裔美国人和白种人中,GM 表型与系统性红斑狼疮无明显关联。然而,白种人患者的 KM 表型频率与对照组有显著差异(p = 0.032)。KM3,3与系统性红斑狼疮的风险增加有关,而KM1,3与系统性红斑狼疮的相对风险降低有关。然而,在非裔美国人中,与 KM 表型相关的模式与白种人不同,患者和对照组之间的总体差异没有统计学意义。
Immunoglobulin GM and KM allotypes in systemic lupus erythematosus.
Genetic variation in immunoglobulin gamma (GM) and kappa (KM) chains was associated with systemic lupus erythematosus (SLE) in some studies. However, the data are conflicting, and only one study examined associations in African-Americans. We examined GM and KM allotypes, by race, in a population-based case-control study of SLE. Sera from patients (n = 222) and controls (n = 273) were typed for GM and KM allotypes by a hemagglutination inhibition method. GM phenotypes were not significantly associated with SLE in African-Americans or Caucasians. However, the frequency of KM phenotypes in Caucasian patients was significantly different from that in controls (p = 0.032). KM3,3 was associated with an increased risk, whereas KM1,3 was associated with a lower relative risk of SLE. In African-Americans, however, the pattern of associations with KM phenotypes differed from that in Caucasians, and the overall difference between patients and controls was not statistically significant.