血管生成素调控细胞凋亡的机制及作用。

L. Shu-ping, H. Guo-fu
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引用次数: 6

摘要

血管生成素(Angiogenin, ANG)是一种分泌性核糖核酸酶,近年来被认为是一种抗凋亡因子,参与多种细胞抗凋亡过程。ANG调节与内在通路相关的主要分子,如抗凋亡蛋白Bcl-2,以及外在信号通路。此外,ANG调节p53调控的细胞凋亡,这一过程被认为在调节外在和内在途径中都很重要。
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Mechanism and Function of Angiogenin in Apoptosis Regulation.
Angiogenin (ANG), a secreted ribonuclease, has been characterized recently as an anti-apoptosis factor involved in a variety of cellular anti-apoptosis process. ANG regulates intrinsic pathways-related major molecules such as anti-apoptotic protein Bcl-2, as well as extrinsic signaling pathways. Moreover, ANG regulates p53-regulated apoptosis, a process considered to be important in regulating both the extrinsic and the intrinsic pathways.
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