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碳酸锂联合长春新碱促进儿童急性T淋巴细胞白血病细胞增殖抑制和凋亡 碳酸锂联合长春新碱促进儿童急性T淋巴细胞白血病细胞增殖抑制和凋亡
中国生物化学与分子生物学报
Pub Date : 2024-05-20 DOI: 10.13865/j.cnki.cjbmb.2024.04.1005
张祚 | 杨爱云 | 路媛芳 | 肖志轩 | 王建华 | 赵丽娇
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引用次数: 0
恰玛古多糖联合顺铂对人肝癌细胞的协同抑制作用及中效原理评价 恰玛古多糖联合顺铂对人肝癌细胞的协同抑制作用及中效原理评价
中国生物化学与分子生物学报
Pub Date : 2023-03-02 DOI: 10.13865/j.cnki.cjbmb.2023.02.1536
孔涵蕊 | 李欣奕 | 张心慧 | 陈赛翕 | 刘政良 | 努尔阿米乃·麦麦提 | 李金玉
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引用次数: 0
药效活性BVOCs物质组与β-牛乳球蛋白选择性结合的分子机制 药效活性BVOCs物质组与β-牛乳球蛋白选择性结合的分子机制
中国生物化学与分子生物学报
Pub Date : 2021-06-21 DOI: 10.13865/j.cnki.cjbmb.2021.06.1177
周清滕 | 郭明 | 胡智燕 | 朱杰丽
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引用次数: 0
基于高分辨质谱及分子对接技术研究适配体与倍氯米松的相互作用 基于高分辨质谱及分子对接技术研究适配体与倍氯米松的相互作用
中国生物化学与分子生物学报
Pub Date : 2021-03-22 DOI: 10.13865/j.cnki.cjbmb.2021.03.1034
樊洪利 | 刘亚雄 | 李苏亚 | 曾文杰 | 罗卓雅
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引用次数: 0
荞麦中光毒物质的转化及荞麦光敏素对人结肠癌细胞HCT-116的抑制活性 荞麦中光毒物质的转化及荞麦光敏素对人结肠癌细胞HCT-116的抑制活性
中国生物化学与分子生物学报
Pub Date : 2018-12-20 DOI: 10.13865/j.cnki.cjbmb.2018.12.09
韩东霞 | 李艳琴 | 杨鹏 | 李彬春
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引用次数: 0
Mechanism and Function of Angiogenin in Prostate Cancer. 血管生成素在前列腺癌中的作用及机制。
中国生物化学与分子生物学报
Pub Date : 2015-12-20 Epub Date: 2015-12-24 DOI: 10.13865/j.cnki.cjbmb.2015.12.06
Nil Vanli, H U Guo-Fu

Angiogenin (ANG), the fifth member of the vertebrate-specific ribonuclease (RNase) A superfamily, is a secreted angiogenic ribonuclease strongly up-regulated in human prostate cancers. ANG is translocated to the nucleus in both prostate cancer epithelial cells and endothelial cells to exert its role in prostate cancer progression by mediating tumor angiogenesis, cancer cell survival and proliferation through rRNA biogenesis. ANG-stimulated rRNA is required not only for prostate intraepithelial neoplasia (PIN) formation, but also for androgen-independent growth of prostate cancer cells. Targeting ANG by various antagonists that inhibit its nuclear translocation, function and/or activity has proven to inhibit prostate cancer growth in animal models. Furthermore, the role of ANG in androgen independence has been firmly established, suggesting a strong rationale for therapeutically targeting ANG in the treatment of castration resistant prostate cancer.

血管生成素(Angiogenin, ANG)是脊椎动物特异性核糖核酸酶(RNase)超家族的第五个成员，是一种在人类前列腺癌中被强烈上调的分泌性血管生成核糖核酸酶。ANG在前列腺癌上皮细胞和内皮细胞中均易位至细胞核，通过rRNA生物发生介导肿瘤血管生成、癌细胞存活和增殖，在前列腺癌的进展中发挥作用。ang刺激的rRNA不仅是前列腺上皮内瘤变(PIN)形成所必需的，也是前列腺癌细胞不依赖雄激素生长所必需的。通过多种拮抗剂抑制ANG的核易位、功能和/或活性，在动物模型中已被证明可以抑制前列腺癌的生长。此外，ANG在雄激素依赖性中的作用已被明确确立，这为靶向ANG治疗去势抵抗性前列腺癌提供了强有力的理论依据。
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引用次数: 11
Mechanism and Function of Angiogenin in Apoptosis Regulation. 血管生成素调控细胞凋亡的机制及作用。
中国生物化学与分子生物学报
Pub Date : 2015-12-01 DOI: 10.13865/J.CNKI.CJBMB.2015.12.05
L. Shu-ping, H. Guo-fu
Angiogenin (ANG), a secreted ribonuclease, has been characterized recently as an anti-apoptosis factor involved in a variety of cellular anti-apoptosis process. ANG regulates intrinsic pathways-related major molecules such as anti-apoptotic protein Bcl-2, as well as extrinsic signaling pathways. Moreover, ANG regulates p53-regulated apoptosis, a process considered to be important in regulating both the extrinsic and the intrinsic pathways.
血管生成素(Angiogenin, ANG)是一种分泌性核糖核酸酶，近年来被认为是一种抗凋亡因子，参与多种细胞抗凋亡过程。ANG调节与内在通路相关的主要分子，如抗凋亡蛋白Bcl-2，以及外在信号通路。此外，ANG调节p53调控的细胞凋亡，这一过程被认为在调节外在和内在途径中都很重要。
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引用次数: 6
检测瓜氨酸和非对称二甲基精氨酸的化学发光方法 检测瓜氨酸和非对称二甲基精氨酸的化学发光方法
中国生物化学与分子生物学报
Pub Date : 2013-03-20 DOI: 10.13865/j.cnki.cjbmb.2013.03.015
张明 | 赵志敬 | 屠慧惠 | 沈文婷 | 王学忠 | 胡广
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引用次数: 0
Screening and Verification of the siRNA Targeted for the FBXL20 Gene FBXL20基因靶向siRNA的筛选与验证
中国生物化学与分子生物学报
Pub Date : 2011-11-28 DOI: 10.3760/CMA.J.ISSN.1006-9801.2011.11.007
Xiu-hong Jia, W. Fan, Jian-chang Li
Objective To obtain effective siRNA fragment of HOXA10 gene and verify its function,to supply experimental evidence for tumor prevention and curation by RNAi targeting to HOXA10 gene.Methods Three pairs of small interfering RNA targeting to the different sites of HOXA10 were designed and introduced into A549.The mRNA expression of HOXA10 of A549 was detected by semi-quantitative RT-PCR,the cell proliferation was assayed by MTT,the apoptosis was measured by flow cytometry.The most effective siRNA assay was screened and was tested the relationship between it and proliferation and apoptosis.Results The mRNA of HOXA10 was inhibited by three siRNAs in A549 cells,among which siRNA1 gave the strongest inhibiting of HOXA10 by ODR was (20.190±1.698) ％.The inhibitory rate of cell proliferation was (69.793±2.092) ％ and the apoptosis rate was (29.593±2.670) ％.Conclusion siRNA1 can specifically degrade HOXA10 mRNA and inhibit the proliferation of A549 cell and promote its apoptosis. Key words: Neoplasms;  Genes, homeobox;  RNA interference;  A549 cell
目的获得HOXA10基因有效siRNA片段并验证其功能，为靶向HOXA10基因的RNAi防治肿瘤提供实验依据。方法设计3对靶向HOXA10不同位点的小干扰RNA并导入A549中。半定量RT-PCR检测A549细胞HOXA10 mRNA表达，MTT检测细胞增殖，流式细胞术检测细胞凋亡。筛选最有效的siRNA检测方法，并检测其与细胞增殖和细胞凋亡的关系。结果A549细胞中HOXA10 mRNA被3种sirna抑制，其中siRNA1对HOXA10的抑制作用最强，为(20.190±1.698)%。细胞增殖抑制率为(69.793±2.092)%，细胞凋亡率为(29.593±2.670)%。结论siRNA1可特异性降解HOXA10 mRNA，抑制A549细胞增殖，促进其凋亡。关键词:肿瘤;同源框基因;RNA干扰;A549细胞
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引用次数: 0
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