介入放射科医师长期低剂量和低剂量率x射线照射的早期和晚期DNA损伤评估

Q4 Medicine International Journal of Low Radiation Pub Date : 2016-01-01 DOI:10.1504/IJLR.2016.10002361

P. Venkatachalam, T.R. Muralidharan, S. Joseph, M. Bhavani, Venkateswarlu Raavi, Sakina Murtaza, Safa Abdul Syed Basheerudeen

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引用次数: 4

摘要

介入医生的职业辐射暴露被认为是医疗从业人员中接受剂量最高的，并有造成DNA损伤的风险。医学专业人员外周血淋巴细胞(PBL) γ-H2AX病灶和不稳定染色体畸变(p > 0.001)明显高于健康志愿者，而易位无显著差异。结果提示，低剂量持续辐射可引起PBL DNA损伤，并可修复或错修复，发展为染色体畸变。

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Assessment of early and late DNA damages in interventional radiologists exposed to protracted low dose and dose rate of X-radiation

Occupational radiation exposures for interventionalists are considered as the highest received doses among medical practitioners and contributing a risk of DNA damage. A significantly higher γ-H2AX foci and unstable chromosomal aberrations (p > 0.001) was observed in Peripheral Blood Lymphocytes (PBL) of medical professionals when compared to healthy volunteers, whereas translocations did not show any difference. The results suggest that low-dose protracted radiation exposure can induce DNA damages in PBL and can get repaired or misrepaired and develop into chromosomal aberrations.

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来源期刊

International Journal of Low Radiation Environmental Science-Health, Toxicology and Mutagenesis

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期刊介绍： The IJLR is a peer-reviewed journal dedicated to the publication of research articles, review papers and technical notes in all domains related to low-dose radiation, among which are the biological and health effects in humans and the biota, in vitro and in vivo research on low radiation effects, regulatory and policy aspects, risk estimation and public perception.