硫酸镁对罗库新斯的明诱导的中度肌松恢复的影响:一项随机对照试验。

IF 1.5 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Magnesium research Pub Date : 2023-06-01 DOI:10.1684/mrh.2023.0514
Jiwon Han, Hee-Yeon Park, Hyun-Jung Shin, Seung Hyun Chung, Sang-Hwan Do
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引用次数: 0

摘要

镁能增强神经肌肉阻滞剂的作用。然而,缺乏证据表明镁对罗库神经肌肉阻滞后新斯的明诱导的恢复可能有影响。本研究比较了镁治疗组(M组)和安慰剂对照组(C组)从神经肌肉阻滞中恢复的情况。64名患者被随机分配到M组或C组。M组的患者接受50mg/kg镁的负荷剂量和15mg/kg/hr的连续输注。C组患者接受了相当量的生理盐水。0.6 mg/kg罗库用于气管插管,并额外给予0.1 mg/kg罗库,以在手术期间维持2-3的TOF状态。手术结束时,给予新斯的明(50μg/kg)加格隆吡咯烷酸酯(10μg/kg),并测量TOF比值为0.7、0.8和0.9的恢复时间。主要结果是从新斯的明给药到TOF比为0.9的恢复时间。此外,还测量了罗库起效时间(从给药罗库到第一次TOF抽搐反应抑制95%的时间)、罗库的额外需求和自发恢复期(从给用药罗库到首次TOF抽搐响应再次出现的时间)。M组和C组新斯的明诱导的恢复时间相当(分别为10.6±4.3和9.1±5.0分钟,p=0.22)。M组罗库起效时间更短,M组自发恢复时间更长。M组额外罗库给药量减少27%,但这一差异并不显著。镁没有显示出延长罗库神经肌肉阻滞后新斯的明诱导的恢复时间,但它增强了罗库的临床效果。
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Effects of magnesium sulphate on neostigmine-induced recovery from moderate neuromuscular blockade with rocuronium: a randomized controlled trial.

Magnesium enhances the effects of neuromuscular blocking agents. However, there is a paucity of evidence demonstrating possible effects of magnesium on neostigmine-induced recovery from neuromuscular blockade with rocuronium. This study compared the profiles of recovery from neuromuscular blockade between groups treated with magnesium (Group M) and placebo controls (Group C). Sixty-four patients were randomly allocated to Group M or Group C. Patients in Group M received a loading dose of 50 mg/kg magnesium and continuous infusion of 15 mg/kg/hr. Patients in Group C received a comparable amount of saline. Rocuronium at 0.6 mg/kg was used for tracheal intubation and 0.1 mg/kg of rocuronium was additionally administered to maintain train-of-four (TOF) status of 2-3 during surgery. At the end of surgery, neostigmine (50 μg/kg) plus glycopyrrolate (10 μg/kg) were administered, and the recovery time for TOF ratios of 0.7, 0.8, and 0.9 was measured. The primary outcome was the time from neostigmine administration to recovery with a TOF ratio of 0.9. In addition, rocuronium onset time (time from administration of rocuronium to 95% suppression of the first TOF twitch response), additional requirements for rocuronium and spontaneous recovery period (the time from administration of rocuronium to reappearance of the first TOF twitch response) were also measured. Neostigmine-induced recovery time was comparable between Group M and Group C (10.6 ± 4.3 vs. 9.1 ± 5.0 min, respectively, p = 0.22). The rocuronium onset time was shorter in Group M, and the spontaneous recovery period was longer in Group M. The amount of additional rocuronium administered was 27% lower in Group M, but this difference was not significant. Magnesium was not shown to prolong neostigmine-induced recovery time from neuromuscular blockade with rocuronium, however, it enhanced the clinical effects of rocuronium.

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来源期刊
Magnesium research
Magnesium research 医学-内分泌学与代谢
CiteScore
3.50
自引率
9.40%
发文量
6
审稿时长
>12 weeks
期刊介绍: Magnesium Research, the official journal of the international Society for the Development of Research on Magnesium (SDRM), has been the benchmark journal on the use of magnesium in biomedicine for more than 30 years. This quarterly publication provides regular updates on multinational and multidisciplinary research into magnesium, bringing together original experimental and clinical articles, correspondence, Letters to the Editor, comments on latest news, general features, summaries of relevant articles from other journals, and reports and statements from national and international conferences and symposiums. Indexed in the leading medical databases, Magnesium Research is an essential journal for specialists and general practitioners, for basic and clinical researchers, for practising doctors and academics.
期刊最新文献
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