微生物共轭亚油酸生物转化研究进展。

IF 14 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Progress in lipid research Pub Date : 2023-10-26 DOI:10.1016/j.plipres.2023.101257
Chen Wu , Haiqin Chen , Yongchao Mei , Bo Yang , Jianxin Zhao , Catherine Stanton , Wei Chen
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引用次数: 0

摘要

共轭亚油酸(CLA)是一种具有益生元特性的功能性食品成分,可为各种人类疾病和病症提供健康益处。然而,动物和植物中有限的天然CLA来源导致乳酸杆菌和双歧杆菌等微生物成为新的CLA来源。微生物将亚油酸转化为CLA是由亚油酸异构酶和多组分酶系统介导的,CLA的生产效率取决于微生物种类和菌株。此外,LA浓度、生长状态、培养基质、前体类型、益生元添加剂和共培养微生物特性等复杂因素强烈影响CLA的产生和异构体组成。本文综述了近十年来微生物CLA生产的进展,包括细菌和真菌。我们强调了CLA的产生和潜在的调节机制,并讨论了利用微生物提高发酵产品的CLA含量和营养价值。我们还确定了主要的微生物CLA生产瓶颈,并提供了应对这些挑战的策略,并通过功能基因和酶挖掘以及下游加工来提高生产。这篇综述旨在为微生物CLA生产提供参考,并拓宽对微生物CLA生产者潜在益生菌作用的理解。
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Advances in research on microbial conjugated linoleic acid bioconversion

Conjugated linoleic acid (CLA) is a functional food ingredient with prebiotic properties that provides health benefits for various human pathologies and disorders. However, limited natural CLA sources in animals and plants have led microorganisms like Lactobacillus and Bifidobacterium to emerge as new CLA sources. Microbial conversion of linoleic acid to CLA is mediated by linoleic acid isomerase and multicomponent enzymatic systems, with CLA production efficiency dependent on microbial species and strains. Additionally, complex factors like LA concentration, growth status, culture substrates, precursor type, prebiotic additives, and co-cultured microbe identity strongly influence CLA production and isomer composition. This review summarizes advances in the past decade regarding microbial CLA production, including bacteria and fungi. We highlight CLA production and potential regulatory mechanisms and discuss using microorganisms to enhance CLA content and nutritional value of fermented products. We also identify primary microbial CLA production bottlenecks and provide strategies to address these challenges and enhance production through functional gene and enzyme mining and downstream processing. This review aims to provide a reference for microbial CLA production and broaden the understanding of the potential probiotic role of microbial CLA producers.

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来源期刊
Progress in lipid research
Progress in lipid research 生物-生化与分子生物学
CiteScore
24.50
自引率
2.20%
发文量
37
审稿时长
14.6 weeks
期刊介绍: The significance of lipids as a fundamental category of biological compounds has been widely acknowledged. The utilization of our understanding in the fields of biochemistry, chemistry, and physiology of lipids has continued to grow in biotechnology, the fats and oils industry, and medicine. Moreover, new aspects such as lipid biophysics, particularly related to membranes and lipoproteins, as well as basic research and applications of liposomes, have emerged. To keep up with these advancements, there is a need for a journal that can evaluate recent progress in specific areas and provide a historical perspective on current research. Progress in Lipid Research serves this purpose.
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