调查 A4 研究中不同种族/族裔、性别和 Aβ 状态组的临床前阿尔茨海默氏症认知综合指数和认知功能指数的因子结构。

IF 8.5 3区医学 Q1 CLINICAL NEUROLOGY Jpad-Journal of Prevention of Alzheimers Disease Pub Date : 2024-01-01 DOI:10.14283/jpad.2023.98

M Ruthirakuhan, M Wood Alexander, H Cogo-Moreira, T Robinson, R Amariglio, R F Buckley, R A Sperling, W Swardfager, S E Black, J S Rabin

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引用次数: 0

摘要

背景：阿尔茨海默病（AD）在不同种族/民族群体之间以及不同性别之间的差异已得到充分证实。神经心理学评估提供了有关认知变化的重要信息，可为了解差异提供有价值的见解。然而，神经心理学测量必须在不同种族/民族和性别/性别群体之间具有可比性，才能准确解释差异：评估临床前阿尔茨海默氏症认知综合征（PACC）和认知功能指数在不同种族/民族、性别和β-淀粉样蛋白（Aβ）状态组间的测量不变性（等效性）：无症状 AD 抗淀粉样蛋白（A4）研究筛查数据的横断面分析。该研究从美国、加拿大、澳大利亚和日本的研究机构招募了 65-85 岁的参与者：参与者完成了 PACC 和认知功能指数。被归类为认知正常的参与者还接受了正电子发射断层扫描（PET），以确定 Aβ 状态：参与者自我认同为非西班牙裔白人（人数=5241）、非西班牙裔黑人（人数=267）、亚裔（人数=228）或西班牙裔白人（人数=225），以及男性（人数=2885）或女性（人数=3076）。在接受 PET 扫描的患者中，3115 人被归类为 Aβ-，1309 人被归类为 Aβ+。我们发现，在全部样本以及按种族/民族、性别和 Aβ 状态分层的样本中，PACC 和认知功能指数的单因素模型均得到支持。PACC和认知功能指数的单因素模型在不同种族/民族、性别和Aβ状态的群体中表现出标度测量不变性：我们的研究结果表明，PACC 和认知功能指数的表现可以在本研究中考察的种族/民族、性别/性別和 Aβ 状况组别之间进行比较。

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Investigating the Factor Structure of the Preclinical Alzheimer Cognitive Composite and Cognitive Function Index across Racial/Ethnic, Sex, and Aβ Status Groups in the A4 Study.

Background: Disparities in Alzheimer's disease (AD) are well-documented among different racial/ethnic groups and between sex/genders. Neuropsychological assessment provides important information about cognitive changes and can offer valuable insights into disparities. However, neuropsychological measures must be comparable across racial/ethnic and sex/gender groups to accurately interpret disparities.

Objectives: To evaluate measurement invariance (equivalence) of the Preclinical Alzheimer Cognitive Composite (PACC) and the Cognitive Function Index across racial/ethnic, sex/gender, and β-amyloid (Aβ) status groups.

Design, setting, participants: Cross-sectional analysis of screening data from the Anti-Amyloid in Asymptomatic AD (A4) Study. The study enrolled participants aged 65-85 from sites across the United States, Canada, Australia, and Japan.

Measurements: Participants completed the PACC and the Cognitive Function Index. Participants classified as cognitively normal also underwent a Positron Emission Tomography (PET) scan to determine Aβ status.

Results: Participants self-identified as non-Hispanic White (n=5241), non-Hispanic Black (n=267), Asian (n=228), or Hispanic White (n=225) as well as male (n=2885) or female (n=3076). Among those who underwent a PET scan, 3115 were classified as Aβ- and 1309 were classified as Aβ+. We found support for a one-factor model for both the PACC and Cognitive Function Index across the full sample and in samples stratified by race/ethnicity, sex/gender, and Aβ status. The one-factor model of the PACC and Cognitive Function Index demonstrated scalar measurement invariance across racial/ethnic, sex/gender, and Aβ status groups.

Conclusions: Our findings suggest that performance on the PACC and Cognitive Function Index can be compared across the racial/ethnic, sex/gender, and Aβ status groups examined in this study.

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来源期刊

Jpad-Journal of Prevention of Alzheimers Disease CLINICAL NEUROLOGY-

自引率

7.80%

发文量

期刊介绍： The JPAD « Journal of Prevention of Alzheimer’Disease » will publish reviews, original research articles and short reports to improve our knowledge in the field of Alzheimer prevention including : neurosciences, biomarkers, imaging, epidemiology, public health, physical cognitive exercise, nutrition, risk and protective factors, drug development, trials design, and heath economic outcomes. JPAD will publish also the meeting abstracts from Clinical Trial on Alzheimer Disease (CTAD) and will be distributed both in paper and online version worldwide.