M Ruthirakuhan, M Wood Alexander, H Cogo-Moreira, T Robinson, R Amariglio, R F Buckley, R A Sperling, W Swardfager, S E Black, J S Rabin
{"title":"调查 A4 研究中不同种族/族裔、性别和 Aβ 状态组的临床前阿尔茨海默氏症认知综合指数和认知功能指数的因子结构。","authors":"M Ruthirakuhan, M Wood Alexander, H Cogo-Moreira, T Robinson, R Amariglio, R F Buckley, R A Sperling, W Swardfager, S E Black, J S Rabin","doi":"10.14283/jpad.2023.98","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Disparities in Alzheimer's disease (AD) are well-documented among different racial/ethnic groups and between sex/genders. Neuropsychological assessment provides important information about cognitive changes and can offer valuable insights into disparities. However, neuropsychological measures must be comparable across racial/ethnic and sex/gender groups to accurately interpret disparities.</p><p><strong>Objectives: </strong>To evaluate measurement invariance (equivalence) of the Preclinical Alzheimer Cognitive Composite (PACC) and the Cognitive Function Index across racial/ethnic, sex/gender, and β-amyloid (Aβ) status groups.</p><p><strong>Design, setting, participants: </strong>Cross-sectional analysis of screening data from the Anti-Amyloid in Asymptomatic AD (A4) Study. The study enrolled participants aged 65-85 from sites across the United States, Canada, Australia, and Japan.</p><p><strong>Measurements: </strong>Participants completed the PACC and the Cognitive Function Index. Participants classified as cognitively normal also underwent a Positron Emission Tomography (PET) scan to determine Aβ status.</p><p><strong>Results: </strong>Participants self-identified as non-Hispanic White (n=5241), non-Hispanic Black (n=267), Asian (n=228), or Hispanic White (n=225) as well as male (n=2885) or female (n=3076). Among those who underwent a PET scan, 3115 were classified as Aβ- and 1309 were classified as Aβ+. We found support for a one-factor model for both the PACC and Cognitive Function Index across the full sample and in samples stratified by race/ethnicity, sex/gender, and Aβ status. The one-factor model of the PACC and Cognitive Function Index demonstrated scalar measurement invariance across racial/ethnic, sex/gender, and Aβ status groups.</p><p><strong>Conclusions: </strong>Our findings suggest that performance on the PACC and Cognitive Function Index can be compared across the racial/ethnic, sex/gender, and Aβ status groups examined in this study.</p>","PeriodicalId":46776,"journal":{"name":"Philosophy of the Social Sciences","volume":"49 1","pages":"48-55"},"PeriodicalIF":0.6000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Investigating the Factor Structure of the Preclinical Alzheimer Cognitive Composite and Cognitive Function Index across Racial/Ethnic, Sex, and Aβ Status Groups in the A4 Study.\",\"authors\":\"M Ruthirakuhan, M Wood Alexander, H Cogo-Moreira, T Robinson, R Amariglio, R F Buckley, R A Sperling, W Swardfager, S E Black, J S Rabin\",\"doi\":\"10.14283/jpad.2023.98\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Disparities in Alzheimer's disease (AD) are well-documented among different racial/ethnic groups and between sex/genders. Neuropsychological assessment provides important information about cognitive changes and can offer valuable insights into disparities. However, neuropsychological measures must be comparable across racial/ethnic and sex/gender groups to accurately interpret disparities.</p><p><strong>Objectives: </strong>To evaluate measurement invariance (equivalence) of the Preclinical Alzheimer Cognitive Composite (PACC) and the Cognitive Function Index across racial/ethnic, sex/gender, and β-amyloid (Aβ) status groups.</p><p><strong>Design, setting, participants: </strong>Cross-sectional analysis of screening data from the Anti-Amyloid in Asymptomatic AD (A4) Study. The study enrolled participants aged 65-85 from sites across the United States, Canada, Australia, and Japan.</p><p><strong>Measurements: </strong>Participants completed the PACC and the Cognitive Function Index. Participants classified as cognitively normal also underwent a Positron Emission Tomography (PET) scan to determine Aβ status.</p><p><strong>Results: </strong>Participants self-identified as non-Hispanic White (n=5241), non-Hispanic Black (n=267), Asian (n=228), or Hispanic White (n=225) as well as male (n=2885) or female (n=3076). Among those who underwent a PET scan, 3115 were classified as Aβ- and 1309 were classified as Aβ+. We found support for a one-factor model for both the PACC and Cognitive Function Index across the full sample and in samples stratified by race/ethnicity, sex/gender, and Aβ status. The one-factor model of the PACC and Cognitive Function Index demonstrated scalar measurement invariance across racial/ethnic, sex/gender, and Aβ status groups.</p><p><strong>Conclusions: </strong>Our findings suggest that performance on the PACC and Cognitive Function Index can be compared across the racial/ethnic, sex/gender, and Aβ status groups examined in this study.</p>\",\"PeriodicalId\":46776,\"journal\":{\"name\":\"Philosophy of the Social Sciences\",\"volume\":\"49 1\",\"pages\":\"48-55\"},\"PeriodicalIF\":0.6000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Philosophy of the Social Sciences\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.14283/jpad.2023.98\",\"RegionNum\":1,\"RegionCategory\":\"哲学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ETHICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Philosophy of the Social Sciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.14283/jpad.2023.98","RegionNum":1,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ETHICS","Score":null,"Total":0}
Investigating the Factor Structure of the Preclinical Alzheimer Cognitive Composite and Cognitive Function Index across Racial/Ethnic, Sex, and Aβ Status Groups in the A4 Study.
Background: Disparities in Alzheimer's disease (AD) are well-documented among different racial/ethnic groups and between sex/genders. Neuropsychological assessment provides important information about cognitive changes and can offer valuable insights into disparities. However, neuropsychological measures must be comparable across racial/ethnic and sex/gender groups to accurately interpret disparities.
Objectives: To evaluate measurement invariance (equivalence) of the Preclinical Alzheimer Cognitive Composite (PACC) and the Cognitive Function Index across racial/ethnic, sex/gender, and β-amyloid (Aβ) status groups.
Design, setting, participants: Cross-sectional analysis of screening data from the Anti-Amyloid in Asymptomatic AD (A4) Study. The study enrolled participants aged 65-85 from sites across the United States, Canada, Australia, and Japan.
Measurements: Participants completed the PACC and the Cognitive Function Index. Participants classified as cognitively normal also underwent a Positron Emission Tomography (PET) scan to determine Aβ status.
Results: Participants self-identified as non-Hispanic White (n=5241), non-Hispanic Black (n=267), Asian (n=228), or Hispanic White (n=225) as well as male (n=2885) or female (n=3076). Among those who underwent a PET scan, 3115 were classified as Aβ- and 1309 were classified as Aβ+. We found support for a one-factor model for both the PACC and Cognitive Function Index across the full sample and in samples stratified by race/ethnicity, sex/gender, and Aβ status. The one-factor model of the PACC and Cognitive Function Index demonstrated scalar measurement invariance across racial/ethnic, sex/gender, and Aβ status groups.
Conclusions: Our findings suggest that performance on the PACC and Cognitive Function Index can be compared across the racial/ethnic, sex/gender, and Aβ status groups examined in this study.
期刊介绍：
For more than four decades Philosophy of the Social Sciences has served as the international, interdisciplinary forum for current research, theory and debate on the philosophical foundations of the social services. Philosophy of the Social Sciences focuses on the central issues of the social sciences, including general methodology (explaining, theorizing, testing) the application of philosophy (especially individualism versus holism), the nature of rationality and the history of theories and concepts. Among the topics you''ll explore are: ethnomethodology, evolution, Marxism, phenomenology, postmodernism, rationality, relativism, scientific methods, and textual interpretations. Philosophy of the Social Sciences'' open editorial policy ensures that you''ll enjoy rigorous scholarship on topics viewed from many different-- and often conflicting-- schools of thought. No school, party or style of philosophy of the social sciences is favoured. Debate between schools is encouraged. Each issue presents submissions by distinguished scholars from a variety of fields, including: anthropology, communications, economics, history, linguistics, philosophy, psychology, and sociology. Each issue brings you in-depth discussions, symposia, literature surveys, translations, and review symposia of interest both to philosophyers concerned with the social sciences and to social scientists concerned with the philosophical foundations of their subjects.
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