O. Latinovic, S. MedinaMoreno, Lauren M. Hippler, J. Zapata, R. Redfield
{"title":"人源化NSG小鼠HIV-1感染模型及其发病机制","authors":"O. Latinovic, S. MedinaMoreno, Lauren M. Hippler, J. Zapata, R. Redfield","doi":"10.15406/JHVRV.2016.03.00088","DOIUrl":null,"url":null,"abstract":"J Hum Virol Retrovirol 2016, 3(2): 00087 Another alternative approach has been to implant human stem cells (HSC) into newborn NSG mice. Both models provide a suitable environment in which to partially reconstitute the human immune system. With adequate numbers of target cells, HIV-1 can replicate without interference from the mouse immune system. The NSG mouse transplantation/engraftment models are the best currently available, as they provide the highest level of human HSC engraftment compared with other immunodeficient strains [1,2].","PeriodicalId":92670,"journal":{"name":"Journal of human virology & retrovirology","volume":"3 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2016-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Humanized NSG Mouse Models of HIV-1 Infection and Pathogenesis\",\"authors\":\"O. Latinovic, S. MedinaMoreno, Lauren M. Hippler, J. Zapata, R. Redfield\",\"doi\":\"10.15406/JHVRV.2016.03.00088\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"J Hum Virol Retrovirol 2016, 3(2): 00087 Another alternative approach has been to implant human stem cells (HSC) into newborn NSG mice. Both models provide a suitable environment in which to partially reconstitute the human immune system. With adequate numbers of target cells, HIV-1 can replicate without interference from the mouse immune system. The NSG mouse transplantation/engraftment models are the best currently available, as they provide the highest level of human HSC engraftment compared with other immunodeficient strains [1,2].\",\"PeriodicalId\":92670,\"journal\":{\"name\":\"Journal of human virology & retrovirology\",\"volume\":\"3 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-04-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of human virology & retrovirology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.15406/JHVRV.2016.03.00088\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of human virology & retrovirology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15406/JHVRV.2016.03.00088","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Humanized NSG Mouse Models of HIV-1 Infection and Pathogenesis
J Hum Virol Retrovirol 2016, 3(2): 00087 Another alternative approach has been to implant human stem cells (HSC) into newborn NSG mice. Both models provide a suitable environment in which to partially reconstitute the human immune system. With adequate numbers of target cells, HIV-1 can replicate without interference from the mouse immune system. The NSG mouse transplantation/engraftment models are the best currently available, as they provide the highest level of human HSC engraftment compared with other immunodeficient strains [1,2].
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