Gustavo Henrique Porto Oliveira, Diogo Brandão, F. Lima, Patricia Batista Lopes do Nascimento, Priscylla Gonçalves Correia Leite de Marcelos, D. M. Pugliesi, L. Cosme-Silva, Valdeci Elias dos Santos Júnior
{"title":"小儿牙科口服咪达唑仑与羟嗪联合使用的疗效和安全性比较:一项系统综述","authors":"Gustavo Henrique Porto Oliveira, Diogo Brandão, F. Lima, Patricia Batista Lopes do Nascimento, Priscylla Gonçalves Correia Leite de Marcelos, D. M. Pugliesi, L. Cosme-Silva, Valdeci Elias dos Santos Júnior","doi":"10.1590/pboci.2023.014","DOIUrl":null,"url":null,"abstract":"ABSTRACT Objective: To assess the efficacy and safety of the use of midazolam as monotherapy, compared to the associated use of midazolam and hydroxyzine for minimum and moderate sedation of children in dental offices, using data obtained from clinical trials. Material and Methods: A systematic review protocol was developed and registered on PROSPERO (CR42020208633). An electronic search was carried out in Pubmed, Lilacs, Science Direct, Open Gray, Web of Science, and central Cochrane Library. No language restrictions were included. Clinical trials were carried out with children aged 0-12 years, using midazolam as monotherapy compared to the use of midazolam associated with hydroxyzine to verify the effectiveness and safety of oral sedation. The quality of the studies was individually assessed and grouped using the RoB 2 (Revised Cochrane risk-of-bias tool for randomized trials) and GRADE (Grading of Recommendations Assessment, Development and Evaluation) systems, respectively. Results: A total of 749 studies were found. After analyzing the inclusion and removal of duplicates, two studies were analyzed for the quality of evidence. Through this analysis, it was possible to verify the very low level of scientific evidence on the superiority of the efficacy and safety of the combined use of midazolam and hydroxyzine for oral sedation in children in dental offices. Conclusion: The conflicting results and limitations of the studies enabled to establish that there is insufficient evidence to support the use of these drugs combined. There is only evidence for the use of midazolam as monotherapy.","PeriodicalId":45592,"journal":{"name":"Pesquisa Brasileira em Odontopediatria e Clinica Integrada","volume":"1 1","pages":""},"PeriodicalIF":0.4000,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Efficacy and Safety of Oral Midazolam Sedation Compared with its Combination with Hydroxyzine Use in Pediatric Dentistry: A Systematic Review\",\"authors\":\"Gustavo Henrique Porto Oliveira, Diogo Brandão, F. Lima, Patricia Batista Lopes do Nascimento, Priscylla Gonçalves Correia Leite de Marcelos, D. M. Pugliesi, L. Cosme-Silva, Valdeci Elias dos Santos Júnior\",\"doi\":\"10.1590/pboci.2023.014\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"ABSTRACT Objective: To assess the efficacy and safety of the use of midazolam as monotherapy, compared to the associated use of midazolam and hydroxyzine for minimum and moderate sedation of children in dental offices, using data obtained from clinical trials. Material and Methods: A systematic review protocol was developed and registered on PROSPERO (CR42020208633). An electronic search was carried out in Pubmed, Lilacs, Science Direct, Open Gray, Web of Science, and central Cochrane Library. No language restrictions were included. Clinical trials were carried out with children aged 0-12 years, using midazolam as monotherapy compared to the use of midazolam associated with hydroxyzine to verify the effectiveness and safety of oral sedation. The quality of the studies was individually assessed and grouped using the RoB 2 (Revised Cochrane risk-of-bias tool for randomized trials) and GRADE (Grading of Recommendations Assessment, Development and Evaluation) systems, respectively. Results: A total of 749 studies were found. After analyzing the inclusion and removal of duplicates, two studies were analyzed for the quality of evidence. Through this analysis, it was possible to verify the very low level of scientific evidence on the superiority of the efficacy and safety of the combined use of midazolam and hydroxyzine for oral sedation in children in dental offices. Conclusion: The conflicting results and limitations of the studies enabled to establish that there is insufficient evidence to support the use of these drugs combined. 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Efficacy and Safety of Oral Midazolam Sedation Compared with its Combination with Hydroxyzine Use in Pediatric Dentistry: A Systematic Review
ABSTRACT Objective: To assess the efficacy and safety of the use of midazolam as monotherapy, compared to the associated use of midazolam and hydroxyzine for minimum and moderate sedation of children in dental offices, using data obtained from clinical trials. Material and Methods: A systematic review protocol was developed and registered on PROSPERO (CR42020208633). An electronic search was carried out in Pubmed, Lilacs, Science Direct, Open Gray, Web of Science, and central Cochrane Library. No language restrictions were included. Clinical trials were carried out with children aged 0-12 years, using midazolam as monotherapy compared to the use of midazolam associated with hydroxyzine to verify the effectiveness and safety of oral sedation. The quality of the studies was individually assessed and grouped using the RoB 2 (Revised Cochrane risk-of-bias tool for randomized trials) and GRADE (Grading of Recommendations Assessment, Development and Evaluation) systems, respectively. Results: A total of 749 studies were found. After analyzing the inclusion and removal of duplicates, two studies were analyzed for the quality of evidence. Through this analysis, it was possible to verify the very low level of scientific evidence on the superiority of the efficacy and safety of the combined use of midazolam and hydroxyzine for oral sedation in children in dental offices. Conclusion: The conflicting results and limitations of the studies enabled to establish that there is insufficient evidence to support the use of these drugs combined. There is only evidence for the use of midazolam as monotherapy.
期刊介绍:
The PESQUISA BRASILEIRA EM ODONTOPEDIATRIA E CLINICA INTEGRADA operates under a continuous publication online modality. This model results in annual volumes, without issue numbers. The main goal of the PESQUISA BRASILEIRA EM ODONTOPEDIATRIA E CLINICA INTEGRADA is to publish results from Original Research as well as Systematic Reviews in the fields of Dentistry and related sciences areas. Its abbreviated title is Pesqui. Bras. Odontopediatria Clin. Integr., and it should be used in bibliographies, footnotes, references and bibliographic strips. PESQUISA BRASILEIRA EM ODONTOPEDIATRIA E CLINICA INTEGRADA encourages submissions from all authors throughout the world. Manuscripts are judged by two experts solely on the basis of their contribution of original data and ideas and their presentation. All manuscripts must comply with Instruction to Authors. The following articles will be considered for publication: Editorials, Original Articles, Systematic Reviews, Short communications and Letters to the Editor.