新型高降解含氯生物活性玻璃

Q1 Materials Science Biomedical Glasses Pub Date : 2015-09-15 DOI:10.1515/bglass-2015-0010
Xiaojing Chen, N. Karpukhina, D. Brauer, R. Hill
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引用次数: 16

摘要

在硅酸盐生物活性玻璃中加入CaF2有利于氟磷灰石的形成,氟磷灰石在酸性环境中比羟基磷灰石更难溶解。然而,过量的CaF2在玻璃中是有问题的,因为在浸泡时形成结晶氟化钙而不是氟磷灰石。本文首次研究了氯化物作为生物活性硅酸盐玻璃中氟化物的替代品,特别是其生物活性。合成了不同CaCl2含量的SiO2-P2O5-CaO-CaCl2熔融衍生生物活性玻璃,并用DSC对其进行了表征。采用离子选择电极对氯化物含量进行了化学分析。玻璃密度用氦密度测定法测定。在Tris缓冲液中研究了玻璃的生物活性。离子释放量采用ICP-OES测定。化学分析结果表明,在Q2型硅酸盐玻璃的合成过程中,大部分氯化物被保留在玻璃中。Tg和玻璃密度随CaCl2含量的增加而降低。通过FITR、XRD和31P MAS-NMR证实了类磷灰石相的形成。体外研究结果表明,含氯生物活性玻璃具有高度可降解性,在Tris缓冲液中3小时内形成磷灰石样相,因此,肯定适合用于再矿化牙膏。玻璃的溶解速率随CaCl2含量的增加而增加。更快溶解的生物活性玻璃可能对更可吸收的骨移植物和支架有吸引力。
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Novel Highly Degradable Chloride Containing Bioactive Glasses
Abstract Addition of CaF2 to a silicate bioactive glass favours formation of fluorapatite, which is less soluble in acidic environment than hydroxyapatite. However, excess CaF2 in the glass is problematic, owing to the formation of crystalline calcium fluoride rather than fluorapatite on immersion. In this paper we investigate chloride as an alternative to fluoride in bioactive silicate glasses and in particular their bioactivity for the first time. Meltderived bioactive glasses based on SiO2-P2O5-CaO-CaCl2 with varying CaCl2 contents were synthesised and characterised by DSC. Chemical analysis of the chloride content was performed by using an ion selective electrode. Glass density was determined using Helium Pycnometry. The glass bioactivity was investigated in Tris buffer. Ion release measurements were carried out by using ICP-OES. The chemical analysis results indicated that the majority of the chloride is retained in the Q2 type silicate glasses during synthesis. Tg and glass density reduced with increasing CaCl2 content. Apatite-like phase formation was confirmed by FITR, XRD and 31P MAS-NMR. The results of the in vitro studies demonstrated that the chloride containing bioactive glasses are highly degradable and form apatite-like phase within three hours in Tris buffer and, therefore, are certainly suitable for use in remineralising toothpastes. The dissolution rate of the glass was found to increase with CaCl2 content. Faster dissolving bioactive glasses may be attractive for more resorbable bone grafts and scaffolds.
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来源期刊
Biomedical Glasses
Biomedical Glasses Materials Science-Surfaces, Coatings and Films
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审稿时长
17 weeks
期刊介绍: Biomedical Glasses is an international Open Access-only journal covering the field of glasses for biomedical applications. The scope of the journal covers the science and technology of glasses and glass-based materials intended for applications in medicine and dentistry. It includes: Chemistry, physics, structure, design and characterization of biomedical glasses Surface science and interactions of biomedical glasses with aqueous and biological media Modeling structure and reactivity of biomedical glasses and their interfaces Biocompatibility of biomedical glasses Processing of biomedical glasses to achieve specific forms and functionality Biomedical glass coatings and composites In vitro and in vivo evaluation of biomedical glasses Glasses and glass-ceramics in engineered regeneration of tissues and organs Glass-based devices for medical and dental applications Application of glasses and glass-ceramics in healthcare.
期刊最新文献
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