The Role of Sleep Deprivation in Arrhythmias

Sleep is essential to the normal psychological and physiological activities of the human body. Increasing evidenceindicates that sleep deprivation is associated with the occurrence, development, and poor treatment effects of variousarrhythmias. Sleep deprivation affects not only the peripheral nervous system but also the central nervous system,which regulates the occurrence of arrhythmias. In addition, sleep deprivation is associated with apoptotic pathways,mitochondrial energy metabolism disorders, and immune system dysfunction. Although studies increasingly suggestthat pathological sleep patterns are associated with various atrial and ventricular arrhythmias, further research is neededto identify specific mechanisms and recommend therapeutic interventions. This review summarizes the findings ofsleep deprivation in animal experiments and clinical studies, current challenges, and future research directions in thefield of arrhythmias.