细胞对分裂辐射剂量和单次辐射剂量与电磁场照射组合的敏感性的比较

Q3 Physics and Astronomy Plasma Medicine Pub Date : 2019-01-01 DOI:10.1615/PLASMAMED.2018027349

Angela Chinhengo, A. Serafin, J. Akudugu

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引用次数: 3

摘要

艾滋病毒呈阳性的个体，患卡波西肉瘤等癌症的风险较高，往往对电离辐射更敏感，开发新的非侵入性方法的风险更高，需要使癌细胞敏感并减少治疗剂量。使用菌落形成试验进行评估。暴露的V79细胞存活分数(SF) = 0.6833 0.0067，分离(SF = 0.5620 0.0026;P = 0.0008)。另一方面，电磁场暴露和辐射联合治疗对黑色素瘤细胞的毒性(SF = 0.3350 0.0050)大于分离放射治疗(SF = 0.3825 0.0035;P = 0.0008)。这些数据表明，使用电磁场可能不会影响肿瘤控制。

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Comparison of Cellular Sensitivity to a Split Radiation Dose and a Combination of a Single Radiation Dose and Electromagnetic Field Exposure

HIV-positive individuals, who are at high risk of developing cancers such as Kaposi’s sarcoma, tend to be more sensitive to ionizing radiation and are at a higher risk of developnew and noninvasive methods are needed to sensitize cancer cells and reduce therapeutic doses. were evaluated, using the colony forming assay. The surviving fraction (SF) of V79 cells exposed = 0.6833 0.0067), was apart (SF = 0.5620 0.0026; P = 0.0008). On the other hand, the combination of EMF exposure and irradiation was more toxic (SF = 0.3350 0.0050) in the melanoma cells than the split radiation treatment (SF = 0.3825 0.0035; P = 0.0008). These data suggest that use of EMF may sigwithout compromising tumor control.

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来源期刊

Plasma Medicine Physics and Astronomy-Physics and Astronomy (all)

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： Technology has always played an important role in medicine and there are many journals today devoted to medical applications of ionizing radiation, lasers, ultrasound, magnetic resonance and others. Plasma technology is a relative newcomer to the field of medicine. Experimental work conducted at several major universities, research centers and companies around the world over the recent decade demonstrates that plasma can be used in variety of medical applications. It is already widely used surgeries and endoscopic procedures. It has been shown to control properties of cellular and tissue matrices, including biocompatibility of various substrates. Non-thermal plasma has been demonstrated to deactivate dangerous pathogens and to stop bleeding without damaging healthy tissue. It can be used to promote wound healing and to treat cancer. Understanding of various mechanisms by which plasma can interact with living systems, including effects of reactive oxygen species, reactive nitrogen species and charges, has begun to emerge recently. The aim of the Plasma Medicine journal will be to provide a forum where the above topics as well as topics closely related to them can be presented and discussed. Existing journals on plasma science and technology are aimed for audiences with primarily engineering and science background. The field of Plasma Medicine, on the other hand, is highly interdisciplinary. Some of prospective readers and contributors of the Plasma Medicine journal are expected to have background in medicine and biology. Others might be more familiar with plasma science. The goal of the proposed Plasma Medicine journal is to bridge the gap between audiences with such different backgrounds, without sacrificing the quality of the papers be their emphasis on medicine, biology or plasma science and technology.