Pub Date : 2023-01-01DOI: 10.1615/plasmamed.2023047282
R. Asada, Takatomo Fujiyama, Ouanthavinsak Bounyang, Jin Sakamoto, H. Matsuura, T. Tsuchido
{"title":"Inactivation of Escherichia coli in small diameter tubes by remote plasmas","authors":"R. Asada, Takatomo Fujiyama, Ouanthavinsak Bounyang, Jin Sakamoto, H. Matsuura, T. Tsuchido","doi":"10.1615/plasmamed.2023047282","DOIUrl":"https://doi.org/10.1615/plasmamed.2023047282","url":null,"abstract":"","PeriodicalId":53607,"journal":{"name":"Plasma Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67349303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.1615/plasmamed.2023050304
Sadia Afrin Rimi, Jaroslav Kristof, Md Jahangir Alam, Oishi kyohei, Okada Takumi, Abubakar Hamza Sadiq, Shimizu Kazuo
Plasma irradiation for drug delivery has attracted significant attention due to its advantages over conventional delivery methods. However, the underlying mechanism of plasma-mediated drug delivery remains largely unexplored. Cell membranes are mainly composed of lipid bilayer which can be easily affected by plasma components, such as reactive species. However, the effects of microplasma irradiation on cell membrane lipids have not been studied before. Therefore, the current study investigated the changes in the lipid packing of cell membranes after microplasma irradiation. In this study, we first optimized the conditions for high molecular weight drug (fluorescein isothiocyanate-dextran, Mw:150 kDa and 2000 kDa) absorption into intestinal epithelial cells. Air microplasma discharge at several voltages (3.5 kV, 4 kV, and 4.5 kV) was applied, and drug absorption was confirmed using a fluorescence microscopy and microplate reader. The best results were achieved at 4 kV in terms of both drug absorption and cell viability. Next, the lipid packing of the membrane was investigated in microplasma irradiated cells (at 4 kV) using lipiORDER dye. The results showed that the membrane lipid order has changed from liquid order phase to liquid disorder phase due to plasma irradiation. The findings of the current study will help understanding the mechanism of cellular drug absorption using microplasma irradiation.
{"title":"Changes in membrane lipid order by microplasma irradiation for high molecule drug absorption","authors":"Sadia Afrin Rimi, Jaroslav Kristof, Md Jahangir Alam, Oishi kyohei, Okada Takumi, Abubakar Hamza Sadiq, Shimizu Kazuo","doi":"10.1615/plasmamed.2023050304","DOIUrl":"https://doi.org/10.1615/plasmamed.2023050304","url":null,"abstract":"Plasma irradiation for drug delivery has attracted significant attention due to its advantages over conventional delivery methods. However, the underlying mechanism of plasma-mediated drug delivery remains largely unexplored. Cell membranes are mainly composed of lipid bilayer which can be easily affected by plasma components, such as reactive species. However, the effects of microplasma irradiation on cell membrane lipids have not been studied before. Therefore, the current study investigated the changes in the lipid packing of cell membranes after microplasma irradiation. In this study, we first optimized the conditions for high molecular weight drug (fluorescein isothiocyanate-dextran, Mw:150 kDa and 2000 kDa) absorption into intestinal epithelial cells. Air microplasma discharge at several voltages (3.5 kV, 4 kV, and 4.5 kV) was applied, and drug absorption was confirmed using a fluorescence microscopy and microplate reader. The best results were achieved at 4 kV in terms of both drug absorption and cell viability. Next, the lipid packing of the membrane was investigated in microplasma irradiated cells (at 4 kV) using lipiORDER dye. The results showed that the membrane lipid order has changed from liquid order phase to liquid disorder phase due to plasma irradiation. The findings of the current study will help understanding the mechanism of cellular drug absorption using microplasma irradiation.","PeriodicalId":53607,"journal":{"name":"Plasma Medicine","volume":"71 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136004010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.1615/plasmamed.2023047705
M. Mahmoud, S. Montaser, A. Elhadary, G. Elaragi
{"title":"Study of the Possible Cytogenetic and Immunological Effects of Cold Atmospheric Pressure Plasma Jet on Whole Blood Cultures of Vitiligo Patients.","authors":"M. Mahmoud, S. Montaser, A. Elhadary, G. Elaragi","doi":"10.1615/plasmamed.2023047705","DOIUrl":"https://doi.org/10.1615/plasmamed.2023047705","url":null,"abstract":"","PeriodicalId":53607,"journal":{"name":"Plasma Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67348875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.1615/plasmamed.2023049438
S. Moritz, R. Bergert, M. Becker, M. Thoma
{"title":"Characterization of Sputter-coated Polyethylene Naphthalate-Foil as Novel Flexible Surface DBD Plasma Source","authors":"S. Moritz, R. Bergert, M. Becker, M. Thoma","doi":"10.1615/plasmamed.2023049438","DOIUrl":"https://doi.org/10.1615/plasmamed.2023049438","url":null,"abstract":"","PeriodicalId":53607,"journal":{"name":"Plasma Medicine","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67349618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.1615/plasmamed.2023048483
T. Pavlik, Nadejda Kostukova, Marina Pavlova, Namik Gusein-zade, N. Shimanovskii
{"title":"Modulation of the effect of doxorubicin and medroxyprogesterone acetate on cytokine and oxidant activity of human leukocytes by Hanks' cold plasma-treated solution","authors":"T. Pavlik, Nadejda Kostukova, Marina Pavlova, Namik Gusein-zade, N. Shimanovskii","doi":"10.1615/plasmamed.2023048483","DOIUrl":"https://doi.org/10.1615/plasmamed.2023048483","url":null,"abstract":"","PeriodicalId":53607,"journal":{"name":"Plasma Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67349535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.1615/plasmamed.2023048516
Miaomiao Xu, Xingxing Li, Yedai Hu, Ge Wang, Yang Yang
{"title":"Experimental Investigation of Low-Pressure Microwave Plasma with Oxygen and Argon for Internal Sterilization of Medical Devices with Slender Catheters","authors":"Miaomiao Xu, Xingxing Li, Yedai Hu, Ge Wang, Yang Yang","doi":"10.1615/plasmamed.2023048516","DOIUrl":"https://doi.org/10.1615/plasmamed.2023048516","url":null,"abstract":"","PeriodicalId":53607,"journal":{"name":"Plasma Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67349549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.1615/plasmamed.2023047628
Avash Shakya, H. Baniya, S. Pradhan, Niroj Basnet, R. Adhikari, D. Subedi, Sagar Regmi
{"title":"Review on Cold Plasma as a Practical Approach to Cancer Treatment","authors":"Avash Shakya, H. Baniya, S. Pradhan, Niroj Basnet, R. Adhikari, D. Subedi, Sagar Regmi","doi":"10.1615/plasmamed.2023047628","DOIUrl":"https://doi.org/10.1615/plasmamed.2023047628","url":null,"abstract":"","PeriodicalId":53607,"journal":{"name":"Plasma Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67348862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.1615/plasmamed.2023047583
S. Darmawati, Defi Nurul Hayati, M. Kamarudin, G. S. A. Putri
{"title":"TNF-α Expression and New Epithelial Thickness in Mice Skin (Mus musculus) Infected MRSA by Medical Plasma Treatment","authors":"S. Darmawati, Defi Nurul Hayati, M. Kamarudin, G. S. A. Putri","doi":"10.1615/plasmamed.2023047583","DOIUrl":"https://doi.org/10.1615/plasmamed.2023047583","url":null,"abstract":"","PeriodicalId":53607,"journal":{"name":"Plasma Medicine","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67349312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.1615/plasmamed.2023050382
Beatrice Olayiwola, Fiona O'Neill, Darren Kavanagh, Liam O'Neill, Rosemary O'Hara
Cold atmospheric plasma (CAP) was used to deposit antibiotics, penicillin, and ciprofloxacin, separately onto titanium coupons. The antibiotic coating parameters were varied using a design of experiment software which factored in plasma power, bacterial and antibiotic load. The antimicrobial activity of the plasma deposited antibiotics was benchmarked against conventional spray coated materials and the effect of the plasma exposure is discussed. The deposited antibiotics were characterized using various surface analysis and microbiological techniques. It was found that the antibiotics were not degraded and retained antibiotic activity against planktonic staphylococcus aureus bacteria. However, the presence of the plasma during coating did alter the elution profile of the antibiotics and helped prolong the activity of the antibiotics on the metal surface. This study may contribute to the development of novel implant coating procedures that can offer prolonged antimicrobial protection.
{"title":"The efficacy of cold atmospheric plasma deposited antibiotics on titanium surfaces and their elution liquids against Staphylococcus Aureus growth over time.","authors":"Beatrice Olayiwola, Fiona O'Neill, Darren Kavanagh, Liam O'Neill, Rosemary O'Hara","doi":"10.1615/plasmamed.2023050382","DOIUrl":"https://doi.org/10.1615/plasmamed.2023050382","url":null,"abstract":"Cold atmospheric plasma (CAP) was used to deposit antibiotics, penicillin, and ciprofloxacin, separately onto titanium coupons. The antibiotic coating parameters were varied using a design of experiment software which factored in plasma power, bacterial and antibiotic load. The antimicrobial activity of the plasma deposited antibiotics was benchmarked against conventional spray coated materials and the effect of the plasma exposure is discussed. The deposited antibiotics were characterized using various surface analysis and microbiological techniques. It was found that the antibiotics were not degraded and retained antibiotic activity against planktonic staphylococcus aureus bacteria. However, the presence of the plasma during coating did alter the elution profile of the antibiotics and helped prolong the activity of the antibiotics on the metal surface. This study may contribute to the development of novel implant coating procedures that can offer prolonged antimicrobial protection.","PeriodicalId":53607,"journal":{"name":"Plasma Medicine","volume":"156 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135104256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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