生酮饮食

Q4 Medicine US endocrinology Pub Date : 2018-01-01 DOI:10.17925/USE.2018.14.2.62
S. Kalra, R. Singla, Rahul Rosha, Munish Dhawan, D. Khandelwal, B. Kalra
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引用次数: 2

摘要

生酮饮食(KD)并不是一种新的治疗选择。事实上,圣经中有关于禁食控制癫痫发作的描述。1921年,葛叶林1对禁食与癫痫发作之间的关系进行了最早的科学观察,特别指出一些患者在禁食期间没有癫痫发作。同年晚些时候,怀尔德推测酮血症对大脑有类似麻醉的镇静作用。他认为,如果给予足够的脂肪,身体就会失去葡萄糖,被迫代谢脂肪,而脂肪又会产生酮体第一个中链甘油三酯(MCT)饮食是由Huttenlocher3在1971年提出的,他还表明MCT饮食的效果取决于酮症的水平。1977年Livingston首次报道了KD的丰富经验4,他说54%的患者在使用KD时癫痫发作完全控制,26%的患者癫痫发作明显减少。考虑到这一历史,KD在治疗顽固性癫痫儿童中仍然发挥着重要作用,这是值得注意的。值得注意的是,我们继续了解KD的作用机制、疗效、适应症和副作用的新信息。KD是一种有效的治疗方法,但并不完全是良性的。它必须经过深思熟虑,仔细实施,并密切监测。
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The Ketogenic Diet
1. Department of Endocrinology, Bharti Hospital, Karnal, India; 2. Department of Endocrinology, Kalpavriksh Healthcare, New Delhi, India; 3. Department of Nutrition, Novique Healthcare, Pune, India; 4. Department of Pediatrics, Miri Piri Hospital, Shahabad, India; 5. Department of Endocrinology, Maharaja Agrasen Hospital, New Delhi, India; 6. Department of Gynecology, Bharti Hospital, Karnal, India
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US endocrinology
US endocrinology Medicine-Endocrinology, Diabetes and Metabolism
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