评价运动和营养对大鼠骨密度的影响

Piri Fatemeh, Khosravi Afra, Derakhshan Siamak, Sayehmiri Kourosh, M. Ardeshir
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引用次数: 1

摘要

前言:本研究旨在通过测定雄性大鼠钙、磷和骨密度(BMD),研究6周补充饮食对增加骨密度的影响。材料与方法:本实验选用15 ~ 20日龄Wistar雄性大鼠24只。将大鼠随机分为3组:免疫系统补充组(ISS)、ISS加运动组和对照组。每日游泳以计时递增的方式进行(从10分钟开始,每天增加10分钟,固定为60分钟)。给大鼠添加含钙、磷的增强免疫系统补剂(5g/kg/d)。6周后,用骨密度仪测量骨密度。用氯胺酮麻醉动物,采集血样分离血清。采用ELISA法测定血清钙、磷含量。结果:两组(ISS加运动组和ISS组)骨密度均高于对照组。在ISS +运动组中,钙、磷和骨密度水平最高。相比之下,对照组中上述标记物的数量最少。结论:ISS对雄性大鼠全身骨密度的影响虽小但有积极作用;此外,研究结果表明,运动和适当营养的结合在增加骨密度方面比适当营养的久坐组更有效。
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Evaluating the effect of exercise and nutrition on bone density in rats
Introduction: The aim of this research was to study the effect of a 6-week supplemented diet on increasing bone density by measuring calcium, phosphorus and bone mineral density (BMD) in male rats. Materials and methods: In this experimental study, 24 Wistar male rats, aged between 15 and 20 days, were selected. The rats were randomly divided into 3 groups: immune system supplement (ISS), ISS plus exercise and control. Daily swimming was performed by timeincreasing (starting from ten minutes and ten minutes was added each day and was fixed at sixty minutes). Supplements strengthening the immune system containing calcium and phosphorus were given to rats (5g/kg/day). After six weeks, BMD was measured using bone densitometer. Animals were anesthetized with ketamine and blood samples were gathered in order to separate their serum. The serum samples were used to measure calcium, phosphorus by the ELISA method. Results: The results showed that in both groups (ISS plus exercise and ISS), BMD was higher than the control group. The highest level of calcium, phosphorus and BMD was seen in the group whose members were ISS plus exercise group. In contrast, the least amount of the mentioned markers was reported in the control group. Conclusion: The results indicate a small but positive effect of ISS on whole body BMD in male rat; also results indicate the combination of exercise and proper nutrition was more effective on increasing the bone density in comparison with the proper nutrition sedentary group.
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