化脓性脑膜炎患儿的脑血管病变

N. Skripchenko, E. Egorova, A. Vilnits, E. Skripchenko, L. A. Alekseeva
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引用次数: 0

摘要

儿童化脓性脑膜炎是一种严重疾病,其特点是死亡率高,特别是在肺炎球菌感染的情况下。化脓性脑膜炎的脑血管病变是决定病程的重要致病因素之一。细菌感染中血管病变(包括脑血管病变)的严重程度取决于患者的年龄和疾病严重程度,这与其病因有关。目标。目的探讨化脓性脑膜炎患儿的脑血管疾病特征,并评估其与疾病病因和严重程度的关系。患者和方法。本研究纳入80例由不同病原体引起的化脓性脑膜炎患儿,年龄1个月至17岁11个月,确认有脑血管病变。除临床监测外,所有患者均进行了凝血试验(包括血小板计数、凝血酶原、纤维蛋白原、活化部分凝血活酶时间和凝血酶时间),并评估d -二聚体和循环内皮细胞水平。结果。我们观察到化脓性脑膜炎儿童的各种血管病变,这是由于血管壁的结构和功能损伤,以及内皮细胞的血管舒缩功能受损。结论。我们发现细胞黄素,一种具有多种作用(包括内皮保护)的药物,对化脓性脑膜炎的治疗有效。关键词:儿童,化脓性脑膜炎,脑血管疾病,血管炎,d -二聚体,循环内皮细胞,细胞黄素
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Cerebrovascular lesions in children with purulent meningitis
Purulent meningitis in children is a severe disease characterized by high mortality, particularly in case of pneumococcal infection. Cerebrovascular lesions in purulent meningitis are one of the most important pathogenic factors that determine the course of the disease. The severity of vascular lesions (including those to cerebral vessels) in bacterial infection depends on patient’s age and disease severity, which is associated with its etiology. Objective. To characterize cerebrovascular disorders in children with purulent meningitis and assess their association with the disease etiology and severity. Patients and methods. This study included 80 children aged 1 month to 17 years and 11 months with purulent meningitis caused by different pathogens and confirmed cerebrovascular lesions. In addition to clinical monitoring, all patients have undergone blood clotting tests (including platelet count, prothrombin, fibrinogen, activated partial thromboplastin time, and thrombin time), and assessment of D-dimer and level of circulating endothelial cells during the disease. Results. We observed various lesions to vessels in children with purulent meningitis, which is attributed to both structural and functional impairments in the vessel wall, as well as to an impaired vasomotor function of the endothelium. Conclusion. We found that cytoflavin, a drug with a multimodal action (including endothelium protection), was effective for the treatment of purulent meningitis. Key words: children, purulent meningitis, cerebrovascular disorders, vasculitis, D-dimer, circulating endothelial cells, cytoflavin
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来源期刊
Infektsionnye Bolezni
Infektsionnye Bolezni Medicine-Infectious Diseases
CiteScore
1.30
自引率
0.00%
发文量
15
期刊介绍: The journal publishes original research works, reviews of literature, lectures, methodological recommendations, clinical observations. Main topics: problems of etiology, pathogenesis, clinical manifestations of infectious diseases, new techniques and methods of their diagnosis, prevention and treatment; special attention is paid to the problems of antibacterial and antiviral therapy, the use of immunoglobulins and interferons, and also to intensive therapy of critical states. The journal is in the List of leading scientific journals and periodicals of the Supreme Attestation Committee, where the principal results of doctoral dissertations should be published.
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