Open-Structure Magnetic Particle Spectroscopy (OMPS): Feasibility Study

Magnetic nanoparticles (MNPs) have been widely used as effective agents for actuation and localization for targeted drug delivery. Especially for the localization of MNPs, magnetic particle imaging (MPI) has been developed to use magnetization generated by a magnetic field. However, most MPI systems use a bore-type structure, and there exist limitations in terms of working space, compatibility with surrounding medical devices, and being able to respond to emergency situations from a medical perspective. To address these issues, we present a novel, open-structure, magnetic particle spectroscopy (OMPS) technique. The structural design, theoretical background, and analysis of the OMPS are presented, and experiments are conducted to evaluate the OMPS. The experimental results indicate that the detection volume can be obtained as a cylindrical region of interest (ROI) of 50 mm × 50 mm × 25 mm, and the feasibility can be exhibited within the same or larger ROI with similar amounts of Resovist as used in previous MPI studies. The results demonstrate the promising potential for OMPS.