毛藻水醇和水乙酸提取物对口蹄疫病毒复制的抑制作用

Q4 Pharmacology, Toxicology and Pharmaceutics Iranian Journal of Pharmaceutical Sciences Pub Date : 2018-01-01 DOI:10.22034/IJPS.2018.32052
Y. Shakiba, S. E. Rezatofighi, S. M. Seyyednejad, M. Ardakani
{"title":"毛藻水醇和水乙酸提取物对口蹄疫病毒复制的抑制作用","authors":"Y. Shakiba, S. E. Rezatofighi, S. M. Seyyednejad, M. Ardakani","doi":"10.22034/IJPS.2018.32052","DOIUrl":null,"url":null,"abstract":"Foot-and-mouth disease (FMD) is a major infectious disease of cloven-hoofed animals that is caused by the FMD virus (FMDV). This disease has significantly adverse economic impacts; therefore, rapid control measures are urgently. Traditional ranchers in Iran use Alhagi maurorum Medik. to treat FMD; therefore, we aimed to examine the antiviral activity of methanolic, ethanolic, and aqueous-acetic acid extracts of this plant against FMDV. The cytotoxicity of the extracts was assayed by the MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide) method and the antiviral activity of the extracts was evaluated by measuring the percentage of viable FMDV infected-cells via the MTT assay at different stages of the virus replication cycle. The results indicated that the plant extracts exhibit antiviral activity against FMDV at all stages of the experiment, although the most significant effects were observed in virucidal and pre-treatment assays. These findings represent the anti-FMDV activities of A. maurorum extracts at several stages of the virus replication cycle; therefore, it could be considered for the potential development of anti-FMDV therapeutics. This creates the basis for further analyses of the molecular mechanisms of the antiviral activity of this herbal plant.","PeriodicalId":14582,"journal":{"name":"Iranian Journal of Pharmaceutical Sciences","volume":"14 1","pages":"85-96"},"PeriodicalIF":0.0000,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Inhibition of Foot-and-Mouth Disease Virus Replication by Hydro-alcoholic and Aqueous-Acetic Acid Extracts of Alhagi maurorum\",\"authors\":\"Y. Shakiba, S. E. Rezatofighi, S. M. Seyyednejad, M. Ardakani\",\"doi\":\"10.22034/IJPS.2018.32052\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Foot-and-mouth disease (FMD) is a major infectious disease of cloven-hoofed animals that is caused by the FMD virus (FMDV). This disease has significantly adverse economic impacts; therefore, rapid control measures are urgently. Traditional ranchers in Iran use Alhagi maurorum Medik. to treat FMD; therefore, we aimed to examine the antiviral activity of methanolic, ethanolic, and aqueous-acetic acid extracts of this plant against FMDV. The cytotoxicity of the extracts was assayed by the MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide) method and the antiviral activity of the extracts was evaluated by measuring the percentage of viable FMDV infected-cells via the MTT assay at different stages of the virus replication cycle. The results indicated that the plant extracts exhibit antiviral activity against FMDV at all stages of the experiment, although the most significant effects were observed in virucidal and pre-treatment assays. These findings represent the anti-FMDV activities of A. maurorum extracts at several stages of the virus replication cycle; therefore, it could be considered for the potential development of anti-FMDV therapeutics. This creates the basis for further analyses of the molecular mechanisms of the antiviral activity of this herbal plant.\",\"PeriodicalId\":14582,\"journal\":{\"name\":\"Iranian Journal of Pharmaceutical Sciences\",\"volume\":\"14 1\",\"pages\":\"85-96\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Iranian Journal of Pharmaceutical Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.22034/IJPS.2018.32052\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Pharmacology, Toxicology and Pharmaceutics\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Iranian Journal of Pharmaceutical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.22034/IJPS.2018.32052","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
引用次数: 3

摘要

口蹄疫(FMD)是由口蹄疫病毒(FMDV)引起的偶蹄动物主要传染病。这种疾病具有显著的不利经济影响;因此,迅速采取控制措施迫在眉睫。伊朗的传统牧场主使用Alhagi maurorum Medik。治疗口蹄疫;因此,我们旨在研究该植物的甲醇、乙醇和水乙酸提取物对FMDV的抗病毒活性。采用MTT(3-[4,5-二甲基噻唑-2-基]-2,5-二苯基溴化四氮唑)法检测提取物的细胞毒性,并通过MTT法测定病毒复制周期不同阶段感染FMDV的活细胞百分比来评估提取物的抗病毒活性。结果表明,植物提取物在实验的所有阶段都表现出抗病毒活性,尽管在病毒杀菌和预处理实验中观察到最显著的效果。这些发现反映了毛蕊草提取物在病毒复制周期的几个阶段的抗口蹄疫活性;因此,可以考虑开发抗fmdv治疗方法。这为进一步分析该植物抗病毒活性的分子机制奠定了基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Inhibition of Foot-and-Mouth Disease Virus Replication by Hydro-alcoholic and Aqueous-Acetic Acid Extracts of Alhagi maurorum
Foot-and-mouth disease (FMD) is a major infectious disease of cloven-hoofed animals that is caused by the FMD virus (FMDV). This disease has significantly adverse economic impacts; therefore, rapid control measures are urgently. Traditional ranchers in Iran use Alhagi maurorum Medik. to treat FMD; therefore, we aimed to examine the antiviral activity of methanolic, ethanolic, and aqueous-acetic acid extracts of this plant against FMDV. The cytotoxicity of the extracts was assayed by the MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide) method and the antiviral activity of the extracts was evaluated by measuring the percentage of viable FMDV infected-cells via the MTT assay at different stages of the virus replication cycle. The results indicated that the plant extracts exhibit antiviral activity against FMDV at all stages of the experiment, although the most significant effects were observed in virucidal and pre-treatment assays. These findings represent the anti-FMDV activities of A. maurorum extracts at several stages of the virus replication cycle; therefore, it could be considered for the potential development of anti-FMDV therapeutics. This creates the basis for further analyses of the molecular mechanisms of the antiviral activity of this herbal plant.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Iranian Journal of Pharmaceutical Sciences
Iranian Journal of Pharmaceutical Sciences Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
0.50
自引率
0.00%
发文量
0
期刊介绍: Iranian Journal of Pharmaceutical Sciences (IJPS) is an open access, internationally peer-reviewed journal that seeks to publish research articles in different pharmaceutical sciences subdivisions: pharmacology and toxicology, nanotechnology, pharmaceutics, natural products, biotechnology, pharmaceutical chemistry, clinical pharmacy and other pharmacy related topics. Each issue of the journal contents 16 outstanding research articles in area of pharmaceutical sciences plus an editorial written by the IJPS editors on one of the most up to date advances topics in pharmacy. All articles published by IJPS would be permanently accessible online freely without any subscription charges. Authors of the published articles have granted the right to use and disseminate their article to third parties.
期刊最新文献
Cytotoxic effect of Tilia dasystyla and Polygonatum orientale Desf extracts on AGS and SKOV-3 cancer cell lines Antibacterial Properties and Flavonoids Content of Some Mosses Common in Armenia Formulation, characterization and evaluation to establish the bioavailability of gastroretentive mucoadhesive dosage of atenolol in human subjects with possible in-vitro-in-vivo correlation Persicoimidate isolated from Allium ampeloprasum Subsp. Persicum with Apoptotic effects against Breast cancer cell lines Information Sharing and Information Quality in the Drugs and Medical Consumables Supply Chain Management (SCM)
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1