巨细胞病毒感染与冠状动脉疾病:伊朗西北部的单中心血清学研究

IF 0.2 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS International Cardiovascular Research Journal Pub Date : 2016-09-30 DOI:10.17795/ICRJ-10(03)118
Z. Khameneh, A. Rostamzadeh, M. Nemati, Paul M Brown, N. Sepehrvand
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引用次数: 2

摘要

慢性巨细胞病毒(CMV)感染和炎症在动脉粥样硬化和冠状动脉疾病(CAD)发病中的作用尚不清楚。目的:本研究旨在探讨在临床怀疑为冠心病而行冠状动脉造影诊断的稳定型心绞痛患者中抗巨细胞病毒抗体和炎症标志物的血清阳性率。患者和方法:对2012年8月至2013年12月在伊朗乌尔米亚Seyyedoshohada心脏医院进行冠状动脉造影诊断的患者中随机抽取181例稳定型心绞痛患者进行横断面描述性研究。根据血管造影结果将患者分为冠心病组和非冠心病组。10、采用酶联免疫吸附法(ELISA)检测抗巨细胞病毒IgG和IgM抗体(Diapron, Rome, Italy)。采用定性方法(Aniston Kit)测定血清c反应蛋白(CRP)。结果:经血管造影检查,141例(77.9%)患者冠状动脉有粥样斑块,40例(22.1%)冠状动脉无斑块。此外,99.3%的CAD组患者和所有非CAD组患者抗cmv IgG阳性。CAD组抗cmv IgM血清阳性率为11.7%,非CAD组为13.2% (P = 0.78)。然而,在有和没有血管造影记录的冠心病组之间,CRP血清阳性没有显著差异(64.7%对56.4%,P = 0.34)。结论:无论是否有血管造影证实的冠心病,在我们的研究中,几乎所有接受冠状动脉造影的病例都曾暴露于巨细胞病毒感染,这是通过血清中抗巨细胞病毒IgG抗体的存在来确定的。事实上,结果表明巨细胞病毒感染和CAD之间没有显著的关联。
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Cytomegalovirus Infection and Coronary Artery Disease: A Single- Center Serological Study in Northwestern Iran
Te role of chronic Cytomegalovirus (CMV) infection and inflammation in the pathogenesis of atherosclerosis and Coronary Artery Disease (CAD) is still not clear. Objectives: Tis study aimed to explore the seroprevalence of anti-CMV antibodies and inflammatory markers in patients with stable angina who had undergone diagnostic coronary angiography for clinical suspicion of CAD. Patients and Methods: Tis cross-sectional, descriptive study was conducted on 181 patients with stable angina selected randomly among the patients referred to Seyyedoshohada Heart Hospital of Urmia, Iran for diagnostic coronary angiography between August 2012 and December 2013. Te patients were categorized into CAD and non-CAD groups based on their angiographic fndings. Ten, anti-CMV IgG and IgM antibodies were tested using the Enzyme-Linked Immunosorbent Assay (ELISA) method (Diapron, Rome, Italy). Serum C-Reactive Protein (CRP) was also measured by a qualitative method (Aniston Kit). Results: Based on angiographic fndings, 141 patients (77.9%) had atheromatous plaques in their coronary arteries, while coronary arteries were free of any plaques in 40 cases (22.1%). Besides, 99.3% of the patients in the CAD group and all the patients in the non-CAD group were anti-CMV IgG positive. Te rate of anti-CMV IgM seropositivity was 11.7% in the CAD group and 13.2% in the non-CAD group (P = 0.78). However, no signifcant difference was observed between the groups with and without angiographicallydocumented CAD in terms of CRP seropositivity (64.7% vs. 56.4%, P = 0.34). Conclusions: Regardless of having angiographically-proven CAD, almost all the cases referred for coronary angiography in our study had a previous exposure to CMV infection as determined by the presence of anti-CMV IgG antibodies in their sera. In fact, the results indicated no signifcant associations between CMV infection and the presence of CAD.
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来源期刊
International Cardiovascular Research Journal
International Cardiovascular Research Journal CARDIAC & CARDIOVASCULAR SYSTEMS-
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50.00%
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