肿瘤心脏病学发展

Bence Prohászka, László Gráf, Zoltán Pozsonyi, J. Forrai
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引用次数: 0

摘要

在我们这个时代,世界范围内导致死亡的主要原因是心血管疾病,其次是癌症疾病。实际上,我们通过多学科合作在癌症治疗方面取得了重大突破,但同时也出现了心脏副作用。几百年前,所有的癌症患者都被认为是不治之症,他们在许多世纪里都被贴上了这样的标签。有些人甚至在我们这个时代也有同样的想法。最早的治疗手段是切除癌组织的外科手术。由于全身麻醉的普及,这些治疗方法在外科手术的世纪蓬勃发展。在19世纪末,一种新的诊断和治疗方法使用了x射线技术,该技术在世界范围内迅速传播。在20世纪中期,科学家开始研究战争中的化学武器,并发现这些武器可以减缓某些癌症的发展。正是由于这些发现,人们发明了第一种抗癌药物氨基optein,从而开启了化疗的时代。然而,几年后,人们意识到一些接受抗曲克林组药物治疗的患者出现了心力衰竭。这一现象促使更多的科学家研究与心脏相关的副作用。后来,在进一步使用HER-2阻滞剂赫赛汀和多激酶抑制剂等化学药物治疗的患者中,观察到类似的副作用,如高血压和心电图异常。这些研究结果在以前接受过化疗的患者的实际心脏病学中越来越受到关注。最后,在2016年,欧洲心脏病学会发布了第一份关于癌症化疗患者副作用的指南,开启了非心脏病学时代。自2016年以来,曾经的心脏病学成为一门新的医学学科,关注并发症的预防,心脏相关副作用的识别和治疗。同年成立了匈牙利onko -心脏病学会,翻译、传播和公布实际指南,并举办研究生培训年度会议。
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Az onkokardiológia kialakulása
In our days, the worldwide leading cause of mortality is cardiovascular, and the second place is held by cancer diseases. Actually, we achieved a significant breakthrough in cancer treatment through multi-disciplinary cooperation but parallel there were emerging cardiac side effects. Several hundred years earlier all cancer patients were considered uncurable, and they were labelled this way through many centuries. Some people are thinking the same way even in our days. The first therapeutic initiatives were surgical operations aiming to remove cancer tissues. These therapeutic approach flourished in the surgeons’ century by spreading of general anaesthesia. At the end of the 19th century, a new diagnostic and therapeutic approach used the X-ray technique which spread fast throughout the world. In the middle of the 20th century, scientist started to investigate the chemical weapons of warfare and discovered, that these lessened the progression of some cancer types. Thanks to these discoveries, there was introduced the first anti-cancer drug aminoptein that opened the era of chemotherapy. However, after a few years, it was realized that some patients treated by pharmaceuticals of the antraciklin groups developed heart failure. This phenomenon instigated more scientists to investigate heart-related side effects. Later, there were observed similar side effects as developing high blood pressure and ECG anomalies in patients treated with further chemicals such as HER-2 blocking herceptin and multi-kinase inhibitors. These researcher outcomes were more and more noticed in the practical cardiology in patients treated previously by chemotherapy. Finally, in 2016 the European Society of Cardiology issued the first guideline about the side effects of cancer chemotherapy patients, which started the era of on-cardiology. Since 2016, the once-cardiology become a new medical discipline that concerns the prevention of complications, and the recognition and treatment of heart-related side effects. In the same year was founded the Hungarian Onko-cardiology Society which is translating, spreading and exposing the actual guidelines and holds annual conferences for postgraduate training.
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