Mucosal immune system in neonatal period and early infancy

The major mechanisms of mucosal defense in the neonate consist of a variety of nonspecific barriers, and innate and specific adaptive immune responses. The functions of innate immunity in the mucosal surfaces are mediated by host-specific microbial–pathogen recognition receptors, designed to recognize unique microbial-associated molecular patterns integral to the structure of most microorganisms. Other mechanisms include many antimicrobial peptides, macrophages, dendritic cells, complement components and host-derived cellular and soluble products. The important elements of neonatal mucosal adaptive immunity include the inductive sites, such as the Peyer’s patches and other lymphoid structures in the respiratory and gastrointestinal tracts, the nasopharyngeal and sublingual tissues, the subepithelial and intraepithelial sites in most external mucosal surfaces, including the genital tract and the mammary glands. These sites contain lymphoid cells derived by the homing of antigen-activated cells from the ind...