皂苷的化学和药理学:特别关注细胞毒性

M. Thakur, M. Melzig, H. Fuchs, A. Weng
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引用次数: 116

摘要

摘要:皂苷是一种主要由植物产生的生物活性化合物,一些海洋生物和昆虫也能产生皂苷。近年来,人们对皂苷类药物作为化学治疗剂的临床应用产生了意想不到的兴趣。对各种形式的皂苷作为癌症治疗手段的研究已经产生了很大的潜力。纳米技术的出现和皂苷增强细胞毒性的特性是近十年来的一些亮点。本文综述了皂苷作为细胞毒性药物的临床潜力,并涵盖了1957-2011年的文献,主要集中在最近十年进行的研究。可以想象,皂苷具有很大的治疗潜力,可以作为鉴定通过膜介导或转运介导途径治疗癌症的合成或半合成分子的先导。
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Chemistry and pharmacology of saponins: special focus on cytotoxic properties
Correspondence: Alexander weng institut fur Laboratoriumsmedizin, Klinische Chemie und Pathobiochemie, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, D-12200 Berlin, Germany Tel +49 30 8445 3097 Fax +49 30 8445 4152 email alexander.weng@charite.de Abstract: Saponins are bioactive compounds produced mainly by plants but also by some marine organisms and insects. In the recent past, there has been unforeseen interest in the clinical utilization of saponins as chemotherapeutic agents. The research on saponins in various forms as a treatment for cancer has generated a lot of potential. The advent of nanotechnology and the cytotoxicity enhancing properties of saponins are some of the highlights of the current decade. This review gives an updated overview of the clinical potential that saponins hold as cytotoxic agents, and covers the literature for 1957–2011, with the main focus on research conducted in the last decade. It is conceivable that saponins hold a lot of therapeutic potential and could be a lead for identification of synthetic or semisynthetic molecules for the treatment of cancer via membrane-mediated or transport-mediated pathways.
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